NON-IONIC SURFACTANT VESICLES (NIOSOMES) BASED NOVEL OPHTHALMIC FORMULATION OF TIMOLOL MALEATE
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 7
Abstract
The objective of the present work was to develop drug loaded niosomal ophthalmic formulation of timolol maleate (an antiglaucomal drug) for enhanced trans-corneal drug permeation and better ocular bioavailability. Timolol loaded niosomes were prepared by thin film hydration method using rotary evapoarator and ultra-sonicated for size reducation using probe sonicator. The nano-vesicle (niosomal) formulation was optimized by selecting surfactant content, cholesterol content and sonication time as independent variables and particle (vesicle) size, drug entrapment efficiency and % drug release as response variables for optimization studies. The timolol maleate niosomal (TMN) formulation was evaluated for particle size, pH and osmolality and was found to possess the desired properties. The developed TMN formulation was studied for % cumulative in-vitro drug release using bottle rotating apparatus (electrolab) and was found to be 79.98% over 8 hr period exhibiting sustained drug release profile. The ex-vivo trans-corneal drug permeation profile of developed TMN was studied using modified franz-diffusion cell apparatus (Permegear) and the % cumulative drug permeation across freshly excised goat cornea was found to be 65.90 % in 8 hrs duration, which was approximately 1.5 times higher than the conventional eye drop formulation. The developed TMN was also proved to be isotonic and non-irritant in HET-CAM ocular irritancy test. It was therefore, concluded from above studies, that the developed timolol maleate niosomal (TMN) formulation is better than conventional eye drops due to longer corneal retention, sustained drug release and better trans-corneal drug permeation and thereby higher ocular bioavailability, hence, would need less frequent administration.
Authors and Affiliations
Prakash Kumar Soni
Keywords
Related Articles
- EP ID EP299109
- DOI -
- Views 58
- Downloads 0
EXPLORATION OF ANTI-HYPERGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES OF ETHANOLIC EXTRACT OF TINOSPORA CARDIFOLIA (WILD)HOOK WHOLE PLANT IN ALLOXAN INDUCED DIABETIC RATS
Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for diabetes mellitus. The aim of present study was to demonstrate the hypoglycemic and anti-diabetic activity of the E...
PRELIMINARY PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF AROGYAVARDHINI COMPOUND- AN EMERGING FORMULATED MEDICINE FOR METABOLIC SYNDROME
Context: Arogyavardhini Compound is an emerging formulated herbo-mineral formulation for treatment of metabolic syndrome. Metabolic syndrome is group of risk factors like, increased waist circumference, insulin resistanc...
Perspectives of Neer-Nirakkuri (colour of the urine) and diagnosis according to Saint Therar
The bioactive compounds and pH of the urine are the reason for dip and spike of its surface appearance. The colour variations relate on its primary and secondary metabolites due to the presence of bacterial reaction. The...
FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF GLICLAZIDE HYDROCHLORIDE
This article illustrates the Formulation and Characterization of Mucoadhesive microspheres of Gliclazide Hydrochloride.The mucoadhesive microspheres were prepared by the Emulsion Solvent Evaporation method by using Eudra...
NOVEL DRY INJECTION FOR RECONSTITUTION OF ASPIRIN USING SOLID SOLUBILISERS
The concept of mixed solvency is an emerging field which can serve as a milestone for solubility enhancement and therefore deserves an urgent attention of the scientific community to assess its efficiency and applicabili...