Non Lupus Full House Nephropathy – A Clinical and Pathological Correlation Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Lupus nephritis is one among the most disabling complications of systemic lupus erythematosus (SLE) as it significantly increases the mortality and morbidity and relentlessly progress to end stage renal disease if not detected and treated promptly. Atypical presentations are well known in SLE and a subset of patients presents with histological evidence of lupus nephritis without other clinical or serological evidence of SLE. Here in this study we analysed the baseline characteristics of 18 such patients with their outcome. Methodology: 18 patients with biopsy proven non lupus full house nephropathy detected after 2012 were followed up till 2017. Their initial clinical, biochemical and histological characteristics were compared with their outcome. Results: 2 patients developed ESRD on follow up and 2 became antibody positive .Low serum C3complement, more globally sclerotic glomeruli and crescents showed statistically significant association with progression to ESRD. Conclusion: The study provides great insight into the details of presentations , biochemical and histological characteristics of non lupus full house nephropathy. The risk factors of faster progression of the disease and evolution of auto antibodies are analysed . Still the true biological nature of this entity is elusive and we recommend more research in this area.
Authors and Affiliations
Dr Gomathy S, Dr Usha Samuel, Dr Arun K A, Dr Pradeep B
Keywords
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- EP ID EP598589
- DOI 10.9790/0853-1603076976.
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