NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR TOPICAL OPHTHALMIC ADMINISTRATION: CONTEMPORARY TRENDS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Topically applied drugs for the treatment of ocular inflammation are the most commonly used formulations due to many reasons: they are simple to use; they can be applied often and provide a high drug concentration; systemic side effects which are associated with oral administration can be avoided. But due to the physiological limitations of the eyes only a small number of anti-inflammatory agents, which have certain physico-chemical properties can be included in appropriate and efficient formulations for treatment of ocular inflammation. To prepare the optimal therapeutic and technological ophthalmic formulation, it is required to know the possibility of enhancing the bioavailability in the ocular tissues and to increase the therapeutic activity of the active substance, by using appropriate technological approaches to create a stable, tolerable and effective ophthalmic drug formulation. In this review, we focus on microemulsions, polymeric NPs, liposomes, SLNs, and nanosuspensions as formulations incorporating non-steroidal anti-inflammatory drugs (NSAIDs) for topical ophthalmic application.Â
Authors and Affiliations
Petya Todorova Peneva
Keywords
Related Articles
- EP ID EP578398
- DOI -
- Views 66
- Downloads 0
AN IMPROVED RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ASPIRIN, ATORVASTATIN, AND CLOPIDOGREL IN PHARMACEUTICAL FORMULATION USING EXPERIMENTAL DESIGN METHODOLOGY
Objective: In this study an improved RP-HPLC method was developed for the simultaneous estimation of Aspirin, Atrovastatin, and Clopidogrel in pharmaceutical dosage form. For improving the separation, an experimental des...
IMMUNOMODULATORY EFFECT OF DIFFERENT PROPORTIONS OF THE HERBAL MIXTURE IN TRIPHALA ON HUMAN T LYMPHOCYTES (MOLT-4)
Objectives: To investigate effect of different proportions of Terminalia bellerica Roxb (TB):Terminalia chebula Retz (TC):Phyllanthus emblica L. (PE) in triphala extract on immunological activity and to determine the pos...
DETECTION OF INTERCELLULAR ADHESION GENES (ICA) IN STAPHYLOCOCCUS AUREUS CAUSING IMPLANT ASSOCIATED INFECTIONS
Objective:The complications related to implant associated infections in post-angioplasty patients were considered to increase due to biofilm formation.Methods: Genes responsible for the biofilm formation in the target or...
STUDY OF ANTIOXIDANT ACTIVITY OF FORMONONETIN BY IN VITRO METHOD
Objective: Now the important field of research in phytomedicine is to search a new plant source as well as new phytoconstituents that have fewer side effects and low cost with the free radical scavenging activity. Method...
PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL EFFICACY STUDIES OF ANNONA SQUAMOSA FRUIT
Objective: The present study was designed to evaluate the antimicrobial activity of lyophilized powder of Annona squamosa fruit. Phytochemical screening was carried out to detect the presence of major phytoconstituents.M...