NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR TOPICAL OPHTHALMIC ADMINISTRATION: CONTEMPORARY TRENDS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 9
Abstract
Topically applied drugs for the treatment of ocular inflammation are the most commonly used formulations due to many reasons: they are simple to use; they can be applied often and provide a high drug concentration; systemic side effects which are associated with oral administration can be avoided. But due to the physiological limitations of the eyes only a small number of anti-inflammatory agents, which have certain physico-chemical properties can be included in appropriate and efficient formulations for treatment of ocular inflammation. To prepare the optimal therapeutic and technological ophthalmic formulation, it is required to know the possibility of enhancing the bioavailability in the ocular tissues and to increase the therapeutic activity of the active substance, by using appropriate technological approaches to create a stable, tolerable and effective ophthalmic drug formulation. In this review, we focus on microemulsions, polymeric NPs, liposomes, SLNs, and nanosuspensions as formulations incorporating non-steroidal anti-inflammatory drugs (NSAIDs) for topical ophthalmic application.Â
Authors and Affiliations
Petya Todorova Peneva
Keywords
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