Nonalcoholic Fatty Liver Disease and Arterial Hypertension: Pathogenetic Factors of Formation and Progression
Journal Title: Гастроентерологія - Year 2014, Vol 2, Issue 52
Abstract
A combination of the most common and socially significant diseases of internal organs, such as arterial hypertension (AH) and nonalcoholic fatty liver disease (NAFLD), may lead to changes in the pathogenetic links of diseases. In this case, the purpose of the work was to determine the mechanisms of formation and progression of AH in patients with NAFLD. The work included 36 patients with concomitant AH and NAFLD and 21 patients with isolated AH. We determined the content of interleukins-1, -2, -4, -6 and -8, circulating immune complexes, the sum of the complement system and the level of the autosensibilization of lymphocytes to self antigens. It is found that the combination of AH and NAFLD leads to changes in the immunological spectrum of blood, which is characterized by an increase in the parameters of inflammatory process (proinflammatory cytokines, the total value of the complement system), resulting in the formation of steatohepatitis. Thus, in the combination of AH and NAFLD there are prerequisites for progression of the pathological process, with the heart, kidneys and liver as a target organs.
Authors and Affiliations
L. M. Pasiyeshvili, N. M. Zheleznyakova, T. M. Pasiyeshvili
Keywords
Related Articles
- EP ID EP225058
- DOI -
- Views 75
- Downloads 0
Development of a non-invasive model to improve the accuracy of determining liver fibrosis stage in nonalcoholic fatty liver disease
Background. The differentiation of mild (F1-F2) and advanced fibrosis (F3-F4), as well as the exclusion of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD), are extremely important for prediction of the...
Diagnostic Value of 200-Minute Postprandial Esophageal Multichannel Intraluminal Impedance-pH-Monitoring in Comparison with 24-Hour Variant
24-hour esophageal multichannel intraluminal impedance (MII)-pH-monitoring is the most accurate method for detecting abnormal gastroesophageal reflux in patients with gastroesophageal reflux disease and other conditions....
Activity of Adipokines and Inflammation in Development of Esophagitis in Overweight Patients with Gastroesophageal Reflux Disease
The aim of the study — to examine the role of adipokines (leptin, adiponectin) and markers of inflammation in the development of gastroesophageal reflux disease (GERD) in obesity. The study included 92 patients, of them...
Ultrasounds Equipment of Medical Institutions of Ukraine and Its Impact on the Incidence of Diseases of the Biliary System
The article presents a study on the impact of ultrasound equipment on the indicators of incidence of diseases of the biliary system using the methods of correlation and regression analyzes. The study analyzed the resourc...
Efficacy of the Treatment for Anxiety-Depressive Disorders in Patients with Gastroenterological Diseases
The article deals with problem of the treatment of anxiety-depressive disorders in patients with gastroenterological disease and persistent symptoms of abdominal pain and dyspepsia. For objectification of psychoemotional...