Nonalcoholic Fatty Liver Disease and Arterial Hypertension: Pathogenetic Factors of Formation and Progression
Journal Title: Гастроентерологія - Year 2014, Vol 2, Issue 52
Abstract
A combination of the most common and socially significant diseases of internal organs, such as arterial hypertension (AH) and nonalcoholic fatty liver disease (NAFLD), may lead to changes in the pathogenetic links of diseases. In this case, the purpose of the work was to determine the mechanisms of formation and progression of AH in patients with NAFLD. The work included 36 patients with concomitant AH and NAFLD and 21 patients with isolated AH. We determined the content of interleukins-1, -2, -4, -6 and -8, circulating immune complexes, the sum of the complement system and the level of the autosensibilization of lymphocytes to self antigens. It is found that the combination of AH and NAFLD leads to changes in the immunological spectrum of blood, which is characterized by an increase in the parameters of inflammatory process (proinflammatory cytokines, the total value of the complement system), resulting in the formation of steatohepatitis. Thus, in the combination of AH and NAFLD there are prerequisites for progression of the pathological process, with the heart, kidneys and liver as a target organs.
Authors and Affiliations
L. M. Pasiyeshvili, N. M. Zheleznyakova, T. M. Pasiyeshvili
Keywords
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