Novel Methods in Nanomedicine for Drug Delivery Systems: Cancer Therapies
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 1
Abstract
Nanotechnology is a general design science that will provide us strong novel implements that may modification every attribute of community. These technologies will location in our hands the potency to design problem at the atomic and molecular level. We will be capable to finally construct available products on-demand and more cheaply. More interestingly, using inherent ideologies and developments, we will design produces that have never existed in nature. The main challenges in the efficient treatment of cancer patients are low effectiveness in drug delivery and inherent drug resistance in extremely heterogeneous human tumors. Chemotherapy drugs have little blood half-lives and confined extents of drugs can be delivered into tumors despite a lot doses of drugs being controlled to patients that reason severe systemic toxicity. Significant attentions when considering the potential that nanotechnology maintain to treat cancer. The recognition of new drug candidates for the remedy of illnesses such as cancer, infectious illnesses, allocates novel tasks for pharmaceutical technology [1]. With attention to drug delivery several problems happen like low bioavailability and hence low solubility or limitation to inappropriate paths of management. Nanotechnological near allow to circumvent several of these difficulties, therefore being well appropriate for future applications as nanomedicines. Furthermore, impressive and enough loading is an acute subject that is approached via nonspherical particles and/or via mesoporous particles both offering larger capacities and levels [2]. Particular attention is placed on the efficacy of figure of particulate materials on the body and associated physiological mechanisms [3]. The changed reply of biological systems on dissimilar shapes opens a novel dimension to regulate particle system interaction [4]. Eventually, the biological reply to these systems wills definition the destiny with respect to their therapeutic value. Consequently, the contact template among nonspherical particulate materials and biological systems as well as the manufacture developments are distinguished [5]. Nevertheless, significant development has been prepared so far during the progress of non spherical drug delivery systems. Also understanding and utilizing the modulation of biological replies by changing particulate figure, the growth of bioavailability of new drugs is a key, challenging difficult in modern drug delivery [6]. A resolution can be given by the use of nanoparticulate materials. While the potential of silica particles, e.g., for example gene carriers, has been shown widespread, the lately developed mesoporous silica nanoparticles permit the delivery of drug mixtures with poor solubility or the controlled deliverance of a drug over a longer time cycle [7]. Moreover, with respect to the use of more efficient and suitable paths of management these progresses will contribute to a more effective therapy in the future. This contains efforts to minimize therapeutic toxicity attended by a higher patient compliance and reduced health care prices. So, nanomedicine based on new methods for drug delivery systems is expected to develop a well-recognized term in modern medicine [8].
Authors and Affiliations
Mozhdeh Haddadi
Keywords
Related Articles
- EP ID EP567588
- DOI 10.26717/BJSTR.2017.01.000154
- Views 193
- Downloads 0
Monitoring Training Intensity; Using a Tri-Phasic Model
Introduction: Different training models can produce the same outcome in competition. As the magnitude of change is dependent on the characteristics of the training programs, the duration of the intervention, and the gend...
Potential Benefits from 3D Printing and Dental Pulp Stem Cells in Cleft Palate Treatments: An In Vivo Model Study
Cleft palate is one of the most frequent anomalies in the head and neck region. Differ-ent treatments have been used but with each, there are still some disadvantages such as fistulas. The use of a 3D scaffold, with oste...
Clinical and Laboratory Features of Systemic Lupus Erythematosus in pediatric patients at Hue Central Hospital, Vietnam
Objectives: To study the clinical characteristics and laboratory profile of systemic lupus erythematosus (SLE) in pediatric Patients at Hue Central Hospital of Vienam. Methods: Children presenting to our Pediatric Center...
PET-CT Based Non-Invasive Radiomic Biomarkers as a Part of Precision Medicine Initiative to Predict Local Recurrences in Oral Cancers
75-80% of patients who are diagnosed with cancer in India have advanced disease(Stage III and Stage IV) that is not amenable to curative treatment, which means that they are likely to have pain and other symptoms and psy...
Systemic Sclerosis: A Multiorgan Disease, Types and Symptoms
Systemic Sclerosis is a chronic condition caused by excessive secretion of collagen inside the body. Some consider it a chronic condition of the connective tissue in the body. Although it is not contagious or cancerous,...