Novel spectrophotometric estimation of Gliclazide by using mixed hydrotropic solubilization phenomenon.
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 4
Abstract
To increase the solubility of Gliclazide which is sparingly soluble in water by using hydrotropic agent i.e. urea, sodium acetate and their combinations. Hydrotropic means to increase in solubility of solute by the addition of high concentrations of alkali metal salts of various organic acids. In hydrotropic solubilization phenomenon, addition of large amount of second solute results in an increase in solubility of another solute. Mixed hydrotropy has been explored in the recent times in order to decrease the amount of hydrotropic agents used for solubility enhancement. Is used in mixed combination, when the ratio of Gliclazide (GZ): Urea (U) 6M: Sodium acetate (SA) 2M then it show about eight times enhancement of solubility. Urea, sodium acetate do not interfere above 225 nm and this mixed hydrotropic method can avoid the toxic and costlier effect caused by the organic solvent It is thus concluded that the proposed methods is new simple, cost-effective, safe, accurate, precise and environmentally friendly.
Authors and Affiliations
Jesika Rane*| Department of Quality Assurance., Dr. Vinod Thakre| Department of Quality Assurance., Dr. R. L. Bakal| Department of Quality Assurance., Suraj Patil| Department of Quality Assurance.
Keywords
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