Novel use of Cytosorb™ haemadsorption to provide biochemical control in liver impairment
Journal Title: Journal of the Intensive Care Society - Year 2019, Vol 20, Issue 2
Abstract
We describe the use of Cytosorb™, a synthetic extracorporeal haemoperfusion adsorption column, in the management of two patients with drug induced cholestasis and a third with alcoholic hepatitis and subsequent acute on chronic liver failure. Cytosorb was used in these patients to remove bilirubin and bile acids by supporting impaired excretory hepatic function, alleviating symptoms with the intention of serving as a bridge to endogenous recovery. The first two cases demonstrate favourable biochemical and symptomatic responses; the third case demonstrated a good biochemical response but subsequently died from the complications of multiple organ failure. These cases suggest Cytosorb™ be evaluated as an adjunct to support liver excretory functions in other arenas, such as acute liver failure or overdose. It remains unclear whether extracorporeal therapies removing liver toxins allow faster or more complete spontaneous recovery of endogenous function.
Authors and Affiliations
VD Dhokia, D Madhavan, A Austin, Craig G Morris
Keywords
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- EP ID EP679559
- DOI 10.1177/1751143718772789
- Views 43
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The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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