Occult Hepatitis B Infection and Its Role in Blood Safety: a Review
Journal Title: Iranian Journal of Blood and Cancer - Year 2013, Vol 5, Issue 2
Abstract
Background: Blood transfusion plays a great role in public health and the blood safety still has remained a main concern. HBV has been considered as one of the most prevalent blood borne infections. It is estimated that chronic HBV affects 350-400 million people worldwide. Comprehensive knowledge about HBV has high importance in Iran due to high number of blood dependent patients. Material and methods: The data used in this research are derived from articles obtained by searching keywords like occult hepatitis B infection, thalassemia, hemophilia, hemodialysis, co-infection and blood transfusion in databases including PubMed, Google Scholar and Scopus. The prevalence, genotypes, HBV-HCV co-infection, HIV-HBV coinfection and their role in blood transfusion and blood safety are discussed in this review article. Results: Iran is in intermediate endemicity region and studies have reported that between 10–60% of the Iranian population has the evidence of HBV infection, with 2-7% being chronic carriers. In blood donors the rate of infection is lower than general population. The occult hepatitis B infection is the main concern in blood safety due to transmission of the HBV via seronegative blood components. Iranian researches have reported a 1-2% prevalence of occult hepatitis B infection among Iranian blood donors. Conclusion: Based on our review findings the prevalence of HBV and occult hepatitis B infection in Iran is moderate, which shows the importance of taking necessary steps to reduce the transfer of infection via blood and its components. Keywords: Hepatitis B virus, prevalence, blood donor, safety.
Authors and Affiliations
Amir Mohammad Alborzi, Omid Kiani Ghalesardi, Taravat Bamdad, Ali Akbar Pourfathollah, Mohammad Ali Jalalifar, Mohammad Shahjahani, Ali Dehghani Fard, Najmaldin Saki
Keywords
Related Articles
- EP ID EP365854
- DOI -
- Views 60
- Downloads 0
University Students Awareness and Attitude towards Blood Donation in Kerman City
Background: Blood transfusion is one of the most crucial needs of the society in multiple diseases and injuries. The only source of blood is donation. Students consist a large and healthy group who are able of providing...
Results of the Pathology of Spleen in 1492 Patients Undergoing Splenectomy
Spleen is a major component of the reticuloendothelial system and functions as a filtering system for the encapsulated bacteria especially in children. Knowing the spectrum of conditions leading to splenectomy in any geo...
Taq1 Polymorphism (rs731236) of Vitamin D Receptor Gene in Children with Acute Lymphoblastic Leukemia
Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Several studies have shown that ALL occurs as a result of genetic abnormalities. 1, 25-Dihydroxyvitamin D3 as a secosteroid hormone play...
The Prevalence of Tumor Lysis Syndrome in Children and Adolescents with Cancer in Hamedan Province, Iran
Background: Tumor lysis syndrome caused by widespread tumor cell damage may lead to electrolyte imbalances and express as metabolic disturbance causing clinical abnormalities. Patients and Methods: All patients younger t...
Serum Levels of Glial Fibrillaryacidic Protein in Meningioma
Background: Glial fibrillaryacidic protein (GFAP), an intermediate filament protein, is mainly expressed by astrocytes, but some other cells like enteric glia and non-myelinating Schwann cells can also express GFAP. GFAP...