Occurrence and clinical characteristics of hepatocellular carcinoma in the north-eastern Poland / Występowanie i cechy kliniczne raka wątrobowokomórkowego wśród chorych z regionu północno-wschodniej Polski
Journal Title: Przegląd Epidemiologiczny - Year 2017, Vol 71, Issue 3
Abstract
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the third leading cause of cancerrelated mortality worldwide. Risk factors for this malignancy include liver cirrhosis, HBV or HCV infection, fatty liver disease. THE AIM OF STUDY: This study aims to assess the occurrence and clinical characteristics of HCC in the Northeastern Poland between 2011 and 2015. The number of primary lesions, their size and location within the liver were analysed. The risk factors for this cancer in studied population have been identified. The usefulness of AFP screening and imaging studies for the diagnosis of HCC were assessed. A preliminary analysis of the efficacy of anti-tumour therapy was performed. RESULTS: Sixty-seven patients (28% female and 72% male) with diagnosed HCC were enrolled. HCC diagnosis was established according to the criteria proposed by the International Consensus Group for Hepatocellular Neoplasia. Of the 67 patients in the study, 7 (10%) were aged 30 to 50 years and 60 patients (90%) were aged 51 years and older. During the period 2011-2015, an increase in HCC incidence was observed. In studied group the most prevalent (31%) were patients with 2 tumours localised in the 6th, 7th or 8th segments of the liver. Metastatic tumours were present in 15% and portal vein thrombosis in 9% of patients. Risk factors assessment revealed that in 72% of patients HCC coexisted with cirrhosis, 33% of patients were HCV-infected, 30% had HBV infection, and 15% were diagnosed with NASH. Elevated serum AFP level was observed in 83% of patients with liver cirrhosis, and in 58% of patients without cirrhosis (p <0.05). Liver transplantation was the best therapeutic option. The efficacy of ablation/resection in combination with sorafenib vs. ablation/partial resection was comparable. CONCLUSION: There has been an increase in the number of HCC cases in North-eastern Poland in last few years. HCC is more common in men aged 50 years and older. Increased serum AFP level is a useful marker for the diagnosis and monitoring of HCC treatment in patients with liver cirrhosis.
Authors and Affiliations
Paweł Kozłowski, Anna Parfieniuk-Kowerda, Aleksandra Tarasik, Mariusz Januszkiewicz, Agnieszka Czauż-Andrzejuk, Tadeusz Wojciech Łapiński, Robert Flisiak
Keywords
Related Articles
- EP ID EP626304
- DOI -
- Views 78
- Downloads 0
Prezenteizm – niezdrowa nadobecność w miejscu zatrudnienia
Transformacje warunków pracy oraz trudności na rynku zatrudnienia nie pozostają bez wpływu na zdrowie pracowników. Sprzyja to powstawaniu nowych zjawisk psychospołecznych w miejscu pracy. Jednym z nich jest prezenteizm (...
Varicella complications in children one-site Polish population – a 19- year long survey / Powikłania ospy wietrznej u dzieci – 19-letnie obserwacje własne
OBJECTIVES: The aim of this study was to describe the epidemiology of chickenpox complications in children, based on a 19-year long survey. METHODS: This publication constitutes a review of medical records of 761 patient...
Foodborne botulism in Poland in 2013
OBJECTIVES. The aim of the study is to assess the epidemiology of foodborne botulism in Poland in 2013. MATERIALS AND METHODS. We reviewed surveillance data published in the annual bulletin “Infectious diseases and poiso...
Outpatient use of systemic antibiotics in Poland: 2004-2008
OBJECTIVES. The goal of this study was to evaluate the quantity and pattern of outpatient antibiotic use in Poland between 2004 and 2008 and to determine the trends in prescribing practice. To investigate the oral and pa...
Posting on „Nie szczepimy („We don’t vaccinate”) Internet forum / Posty na internetowym forum „Nie szczepimy”
INTRODUCTION. In Poland, there is a visible strengthening of hesitant attitudes towards vaccination, as well as institutionalization and politicization of hesitancy. The Internet is an important source of information abo...