Ocena jakości snu w odniesieniu do stężenia serotoniny i melatoniny w surowicy u osób z marskością wątroby
Journal Title: Folia Medica Lodziensia - Year 2014, Vol 41, Issue 2
Abstract
Sleep disorders occur in people who suffer from liver cirrhosis, this usually involves a change in the rhythm of melatonin secretion and its metabolism. Delayed sleep phase syndrome does not always correlate with the degree of liver damage, indicating the involvement of other factors in its pathogenesis. The aim of the study was to estimate the correlation between the night secretion of the serotonin and melatonin and the degree of sleep disorders. There were 60 patients with liver cirrhosis and 30 healthy subjects (control group) included in the study. Compared to the control group, in the first stage of hepatic encephalopathy (according to West Haven Scale) at 2 o’clock a.m. a low serum melatonin level was observed (57.5±10.2 pg/mL and 41.2±9.4 pg/mL, p<0.05) and even lower concentration of serotonin (171.2±45.0 and 108.4±29.3 μg/mL, p<0.01). These results negatively correlated with the degree of sleep disorders. The obtained results indicate that in patients with liver cirrhosis the changes in the homeostasis of both serotonin and melatonin occur, which can cause sleep disorders.
Authors and Affiliations
Karolina Tomaszewska-Warda, Ewa Walecka-Kapica, Monika Pawłowicz, Cezary Chojnacki, Patrycja Wachowska-Kelly
Keywords
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