Udział zaburzeń szlaku FGF/FGFR w transformacji nowotworowej piersi, jajnika oraz błony śluzowej trzonu macicy
Journal Title: Folia Medica Lodziensia - Year 2014, Vol 41, Issue 1
Abstract
Fibroblast growth factors (FGFs) and their receptors (FGFRs) are the members of a large protein family involved in the regulation of many cellular processes which are essential for proper functioning of cells. It was found that the disregulation of FGF/FGFR signaling pathway can lead to the cancero-genesis of many tissues including the breast, the ovary and the endometrium. The alteration in FGF and FGFR gene expression and their mutation may induce growth and survival signals and suppress apoptosis. The Disregulation of FGF/FGFR signaling pathway can also promote endocrine therapy resistance.
Authors and Affiliations
Ewa Forma, Agnieszka Szymczyk
Keywords
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