Ocena profilu lipidowego u pacjentów aglomeracji łódzkiej leczonych statynami
Journal Title: Folia Medica Lodziensia - Year 2014, Vol 41, Issue 1
Abstract
Introduction: In more than the half of the population in Europe, including Poland, blood lipid profile is abnormal. These abnormalities are: high total cholesterol (TCh) levels (> 5.0 mmol/L or 190 mg/dL), often accompanied by the increased concentrations of cholesterol (Ch) in the atherogenic LDL (LDL Ch) and theelevated levels of triglycerides (TG). In some people we also observe thedecrease in the concentration of Ch in antyatherogenic HDL (HDL Ch, so called "good cholesterol"). Such abnormalities lead to the progression of atherosclerosis and, consequently, to the increase in the occurrence of cardiovascular diseases (CVD) which are the leading causes of death worldwide. In maintaining proper blood lipid profile a lipid-lowering therapy with the use of statins is recommended, in addition to maintaining a proper diet and increased physical activity. The aim of this study was to compare the lipid profile (TCh, LDL-Ch, HDL-Ch and TG) in two groups of patients of Lodz population: in a group of patients receiving statins vs a group of patients without corresponding treatment. This will also allow to evaluate the impact of statins on improving the lipid profile in subjects. Material and methods: The study involved 91 patients (57 women and 34 men, at the age from 36 to 81 years, mean 62 years) of Primary Health Care of the Military Teaching Hospital of Lodz - Central Veterans Hospital. We created 2 groups: group A (n=52, 35 women and 17 men) taking regularly statins and control group K (n=39, 22 women and 17 men). In all the patients the basic parameters of the lipid profile were assessed: TCh, HDL-Ch, LDL-Ch and TG. Results: There was a statistically relevant lower level of TCh in the whole group A in comparison to group K (4.70 vs. 5.88 mmol/L with a recommended level of < 5.0 mmol/L) and the LDL-Ch (2.97 vs 4.14 mmol/L with a recommended level of < 3.0 mmol/L). We found that in group A the recommended values for all 4 lipid profile parameters were present in 17 of 52 patients (32.7%), while in group K only in 2 of 39 patients (5.1%). Conclusion: Lipid profile (TCh, LDL-Ch, HDL-Ch and TG) in patients undergoing treatment with statins is significantly closer to the recommended values comparing to untreated patients. This applies particularly to significantly lower levels of TCh and LDL-Ch in patients that undergo treatment. The results confirm the previous data that a proper lipid-lowering therapy significantly effects in the reduction of the risk of cardiovascular disease by adequate maintenance of lipid profile.
Authors and Affiliations
Dominika Porembińska, Marek Paradowski, Kamila Olszowiec, Rafał Wlazeł
Keywords
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