Rola mesalazyny w chemoprewencji raka jelita grubego
Journal Title: Folia Medica Lodziensia - Year 2014, Vol 41, Issue 2
Abstract
Colorectal cancer (CRC) is the fourth most commonly diagnosed cancer in females and the third in males. Every year there are more than a million new cases of colorectal cancer and more than six hundred thousand patients die. The risk factors of colorectal cancer include unhealthy lifestyle, genetic predisposition (found in about 25% of cases) and chronic colon inflammation i.e., ulcerative colitis and Crohn's disease. Many studies suggested the protective effect of nonsteroidal anti-inflammatory drugs, including mesalazine, on the chemoprevention of colorectal cancer. Studies have shown that the regular intake of mesalazine reduces the risk of developing colorectal polyps and cancer by its multidirectional action. Anti-inflammatory mechanisms include the modulation of inflammatory cytokine production, COX inhibition and impact on NF-κB and PPARδ pathways. Consequently, mesalazine inhibits, or at least delays, the processes of carcinogenesis.
Authors and Affiliations
Andrzej Wasilewski, Adam Cygankiewicz
Keywords
Related Articles
- EP ID EP169446
- DOI -
- Views 106
- Downloads 0
Elektroforetyczna identyfikacja proteinaz cysteinowych w surowicach pacjentów z przewlekłą białaczką limfocytową (PBL) z wykorzystaniem biotynylowanego jodoacetamidu
Introduction: Cysteine proteases are enzymes that regulate numerous physiological and pathological processes in the human body. Disorders of their activity can lead to a number of diseases. They play an important role in...
Ocena profilu lipidowego u pacjentów aglomeracji łódzkiej leczonych statynami
Introduction: In more than the half of the population in Europe, including Poland, blood lipid profile is abnormal. These abnormalities are: high total cholesterol (TCh) levels (> 5.0 mmol/L or 190 mg/dL), often accompan...
Biochemiczna ocena skuteczności leczenia pacjentów z akromegalią
Introduction: The main treatment for acromegaly is the surgical removal of the tumour. Pharmacotherapy, usually with somatostatin analogues (SSA), is used as the preliminary and/or complementary therapy. In the diagnosis...
Analiza częstości występowania polimorfizmu C421A genu ABCG2 w przypadkach raków żołądka w regionie łódzkim
Introduction: In the present thesis the association between the variants of C421A polymorphism of ABCG2 gene and the risk of gastric cancer development were searched. The occurrence of polymorphic variant 421 C > A leads...
Wydzielanie serotoniny i melatoniny oraz mioelektryczna i motoryczna czynność żołądka u kobiet po menopauzie
In postmenopausal women various psychosomatic disorders concerning mood and appetite occur. The reason is not only estrogen deficiency, but also other hormones and neurotransmitters. The aim of the study was to estimate...