Ocular Findings and Multimodal Imaging Characteristics of Retinitis Pigmentosa Patients
Journal Title: Hamidiye Medical Journal - Year 2021, Vol 2, Issue 1
Abstract
Background: To investigate the ocular findings and multimodal imaging characteristics of retinitis pigmentosa (RP) patients. Materials and Methods: Patients who were followed up in our clinic for RP were evaluated retrospectively between June 2014 and July 2017. Ophthalmological examination included best corrected visual acuity (BCVA), biomicroscopy, fundoscopy, and axial length (AL) measurements. Optical coherence tomography (OCT) and fundus autofluorescence (FAF) imaging properties of macular region were examined in detail. Results: In the study, 865 eyes of 446 RP patients were evaluated. In biomicroscopic examination, cataract surgery was performed in 23.6% of the eyes, and 29.1% of the eyes had posterior subcapsular cataract. In fundus examination, end-stage RP was detected in 67.4% of the eyes and severe macular atrophy in 9.8% of the eyes. The mean AL was 23±1.8 mm, the mean central macular thickness (CMT) was 136.6±87.1 um, and the mean subfoveal choroidal thickness (SCT) was 178.3±89.1 um. There was a positive correlation between BCVA and CMT, SCT, external limiting membrane and ellipsoid zone line integrity (p<0.001). Inner limiting membrane thickening and/or epiretinal membrane 47.7%, intraretinal hyperreflective foci 43.1%, micropseudocyst 15.8% and cystoid macular edema 6.5% were among the most commonly seen macular abnormalities detected in OCT. There was presence of a hyper-autofluorescent (AF) ring in 28.4%, abnormal hyper-AF patterns at the macula in 45.3%. There was a positive correlation between external limiting membrane-ellipsoid zone line integrity and the hyper-AF ring (p<0.001). Conclusion: Screening RP patients using OCT, FAF and biometry findings may be useful both for documenting of the disease and for selecting candidates for innovative treatment modalities like retinal prosthesis, stem cell therapy.
Authors and Affiliations
Semra Tiryaki Demir, Dilek Güven, Hakan Kaçar, Saniye Üke Uzun, Murat Karapapak
Keywords
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- EP ID EP693716
- DOI 10.4274/hamidiyemedj.galenos.2021.46855
- Views 162
- Downloads 0
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