Analysis of Severe and Critical COVID-19 Patients Treated With Favipiravir: A Retrospective Cohort Study
Journal Title: Hamidiye Medical Journal - Year 2021, Vol 2, Issue 1
Abstract
Background: We aimed to analyze demographic characteristics, smoking status, comorbidities, laboratory parameters and other treatments before favipiravir use in severe to critically ill patients with coronavirus disease-2019 (COVID-19) who were treated with favipiravir in Turkey. Materials and Methods: This study was conducted as a retrospective observational study in a tertiary reference hospital for COVID-19. Clinical and laboratory data of COVID-19 patients who were consecutively treated with favipiravir were evaluated. The patients were divided into two groups as survivors and non-survivors. Results: The mean ages of the non-survivors and survivors were 67.3±13.3 and 57.3±16.4 years (p<0.0001), respectively. The smoking rate was 44.4% in non-survivor group and 9.1% in the survivor group (p=0.01). Older age [odds ratio (OR): 1.04, 95% confidence interval (CI): 1.016-1.069], smoking (OR: 5.76, 95% CI: 1.84-18.03), presence of one or more comorbidity (OR: 4.43, 95% CI: 1.79-10.91), coronary artery disease (CAD) (OR: 2.66, 95% CI: 1.06-6.72), arrhythmia (OR: 3.4, 95% CI: 1.78-9.82) and congestive heart failure (CHF) (OR: 14.4, 95% CI: 2.9-71.43) were significantly related to mortality (p<0.05). The rate of patients who were treated with lopinavir/ritonavir before favipiravir was higher in the non-survivor group (p=0.0001). Favipiravir treatment was started earlier in survivors than in non-survivors (3.1±2.2 and 4.7±3.4 days, respectively, p=0.006). Conclusion: Older age, smoking, presence of one or more comorbidity, CAD, arrhythmia, CHF and treatment with lopinavir/ritonavir before favipiravir were associated with mortality. Favipiravir was started earlier in survivors. Oxygen saturation levels and platelet count increased, and C-reactive protein (CRP) and lactate dehydrogenase levels decreased with favipiravir treatment in survivors. Higher CRP levels were also associated with mortality.
Authors and Affiliations
Bengü Şaylan, Tayfun Çalışkan
Keywords
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- EP ID EP693721
- DOI 10.4274/hamidiyemedj.galenos.2021.29591
- Views 131
- Downloads 0
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