Ocular Manifestations of Sildenafil citrate: A Rare Case Report
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 1
Abstract
Sildenafil citrate a Phosphodiesterase type-5 (PDE-5) inhibitor is well tolerated and efficacious treatments for male erectile dysfunction that currently rank among the best-selling drugs worldwide. Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported rarely post-marketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including MANFORCE. Most, but not all, of these patients had underlying anatomic or vascular risk factors for developing NAION, including but not necessarily limited to: low cup to disc ratio (“crowded disc”), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia and smoking. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors, to the patient's underlying vascular risk factors or anatomical defects, to a combination of these factors, or to other factors. It also exerts a minor inhibitory action against PDE6, which is present exclusively in rod and cone photoreceptors. At higher doses, sildenafil causes mild and transient visual symptoms in a minority of patients (mainly blue tinge to vision, increased brightness of lights) causing definite effect in transient, mild impairment of colour discrimination. But in this case, rare types of allergic ocular manifestations are mentions below, which are not reported before.
Authors and Affiliations
Santosh Kumar Singh, (Col). Zahiruddin Khan
Keywords
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- EP ID EP542576
- DOI 10.21276/ijmrp.2017.3.1.039
- Views 70
- Downloads 0
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