OCULAR SURFACE AND GLAUCOMA MEDICAL THERAPY
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 12
Abstract
Purpose: To compare the impact on the ocular surface of glaucomatous patients under monotherapy by latanoprost, tafluprost, bimatoprost and bimatoprost/timolol 0.50% fixed combination. Patients and Methods: This is a single center, clinical and epidemiological study. Fourty glaucomatous patients (20 males; 20 females), age and sex-matched were divided in four groups according to monotherapy (latanoprost 0.005%, tafluprost 0.0015%, bimatoprost 0.03% and bimatoprost 0.03%/timolol 0.50% fixed combination). All of these patients had at least three months follow-up and were under tonometric control. All of these patients were categorized according to a new algorithm to classify the clinical and familiar risk factors. All of them received OSDI and NEI-VFQ-25 questionnaires to evaluate their quality of life under monotherapy. The statistical analysis was performed by Student’s t-test as for demographical data and one-way ANOVA as for the questionnaires results. P<0.05 was considered statistically significant. Results: All the glaucomatous patients answered their questionnaires. According to the different groups, latanoprost group had a p=0.302, tafluprost group p=0.381, bimatoprost/timolol 0.50% fixed combination p=0.141 and bimatoprost group p=0.000. Conclusions: All the glaucomatous patients completed this study. The Author hypothesizes that the bimatoprost group is the only statistical significant because bimatoprost is a drug usually prescribed in advanced glaucomatous patients, where the clinical picture and the ocular surface are usually more damaged than in the early stage of glaucoma disease.
Authors and Affiliations
Prof. Dr. Italo Giuffre
Keywords
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