Olanzapine-Induced Cirrhosis and Hepatocellular Carcinoma by Hepatotoxicity in An Elder Chinese Woman: Case Report and Review of The Literature
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 3
Abstract
Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness, we present a case of a 75-year-old Chinese woman with schizophrenia for 30 years who used a long-term use of olanzapine developed to cirrhosis and hepatocellular carcinoma. We used RUCAM (Method for causality assessment of adverse drug reactions) to score 7 points by hepatotoxicity of olanzapine. Pathologist thought the patient probly caused by non-alcoholic steatohepatitis (NASH) for establishing the diagnosis of steatohepatitis are based on the presence of abnormalities associated with significant hepatocellular injury in the setting of steatosis. We expect to see patients receiving olanzapine should be educated about its potential adverse effects and complications.Hepatitis and cholestatic jaundice are common complications of the use of conventional antipsychotics, particularly chlorpromazine. Olanzapine is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness [1], olanzapine is not infrequently associated with serum aminotransferase elevations during therapy and there have been rare instances of clinically apparent acute liver injury linked to its use. Liver test abnormalities have been reported to occur in 10% to 50% of patients on long term therapy with olanzapine [2]. These abnormalities are usually mild, asymptomatic and transient, and can reverse even with continuation of medication [3]. We present a rare case. A elder Chinese woman with cirrhosis and hepatocellular carcinoma maybe induced by a longtime olanzapine- hepatotoxicity.
Authors and Affiliations
Youwen Tan, Xinbei Zhou
Keywords
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- EP ID EP621805
- DOI 10.26717/BJSTR.2019.19.003308
- Views 162
- Downloads 0
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