OLD AND NEW EMERGING THEREPIES FOR MULTIPLE SCLEROSIS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
Multiple sclerosis (MS) is an autoimmune disease that is characterized by central nervous system inflammation, demyelination, and axon loss. It’s affect up to two million people world wide and represents a prime cause of neurological disability in young adults and has wide health, psychological, economical and social consequences. Experimental autoimmune encephalomyelitis (EAE), an animal model of human MS, is a demyelinating, inflammatory disease of the CNS and is induced by the immunization of susceptible strains of rats or mice with myelin antigens combined with adjuvant. The current treatments for MS progression include disease modifying agent viz. cytostatic, immunomodulatory drugs such as mitoxantrone and cyclophosphamide (CY), biological agents such as interferon (IFN)-beta, natalizumab and the random polymer glatiramer acetate. Although clear-cut beneficial effects are observed in many patients treated with these drugs, in addition, all of these compounds have potentially serious side effects, some require systemic administration and the biological agents are costly and immunogenic, causing response failure during prolonged treatment. The present review compiled the data on those agents which shows promising affect in different clinical trial of MS and its animal model EAE and therefore used in treatment of MS in future.
Authors and Affiliations
Akanksha Kulshreshtha, Hansraj Manda
Keywords
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