Omeprazole does not change the oral bioavailability or pharmacokinetics of vinpocetine in rats.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 5
Abstract
Previous studies proved that food strongly enhanced the bioavailability of vinpocetine. Food may change the pharmacokinetics of a drug by affecting various factors, including gastrointestinal pH. However, the influence of proton pump inhibitor-induced pH alterations on vinpocetine pharmacokinetics is not known. The aim was to evaluate the influence of omeprazole on the pharmacokinetics of oral vinpocetine. One group of male Wistar rats received single oral doses of vinpocetine (2 mg/kg - regimen V). In the second group, omeprazole (10 mg/kg) was administered intraperitoneally for 5 days before vinpocetine administration (regimen OV). For analysis of vinpocetine pharmacokinetics, blood samples were obtained before and 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12 h after vinpocetine administration. Vinpocetine concentrations were measured by high performance liquid chromatography (HPLC). The mean values of AUC(0-t), AUC(0-inf) and C(max) in regimen V were very similar to respective values in regimen OV. The mean T(max) in both regimens was estimated for 1.5 h. There were no statistically significant differences between both regimens. In conclusion, omeprazole did not affect the pharmacokinetic profile of vinpocetine.
Authors and Affiliations
Tomasz Sozański, Jan Magdalan, Małgorzata Trocha, Antoni Szumny, Anna Merwid-Ląd, Wojciech Słupski, Marta Karaźniewicz-Łada, Grzegorz Kiełbowicz, Dorota Ksiądzyna, Adam Szeląg
Keywords
Related Articles
- EP ID EP97577
- DOI -
- Views 100
- Downloads 0
Effect of kaempferol on the production and gene expression of monocyte chemoattractant protein-1 in J774.2 macrophages.
Monocyte chemoattractant protein-1 (MCP-1) is produced by activated macrophages, and is involved in pathogenesis of cardiovascular and neurodegenerative disorders. There is a need to develop drugs that inhibit excessive...
Involvement of cholinergic receptors in the different stages of memory measured in the modified elevated plus maze test in mice.
Background and Methods: Several lines of evidence support a strong relationship between cholinergic pathways and memory. The aim of our experiments was to examine the mechanisms involved in the formation of different mem...
Delta opioid receptors contribute to the cardiorespiratory effects of biphalin in anesthetized rats.
Biphalin expresses almost equal affinity for μ- and δ-opioid receptors. The aim of this study was to delineate a possible role of δ-opioid receptors in the cardio-respiratory effects of systemic injection of biphalin in...
Chronic ethanol tolerance as a result of free-choice drinking in alcohol-preferring rats of the WHP line.
The development of tolerance to alcohol with chronic consumption is an important criterion for an animal model of alcoholism and may be an important component of the genetic predisposition to alcoholism. The aim of this...
Anticonvulsant and antidepressant activity of the selected terpene GABA derivatives in experimental tests in mice.
The present study was designed to investigate the central nervous system activity of terpene GABA (and piracetam) derivatives designated as BF-1, BF-2, BF-3, BF-4, BF-5, BF-6. We assessed their anticonvulsant activity in...