Oncogenic Human Papillomavirus Genotypes and Cervical Cancer: A Focus on Multiple Infections and Patient Age
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 8
Abstract
ABSTRACT Introduction: Cervical cancer is the leading cause of cancer-related deaths in the female population. Human Papillomavirus (HPV) genotypes 16 and 18 accounts for 70% of cervical cancer cases. HPV infection is associated with the development of cervical carcinoma and its precancerous lesions, and early intervention can effectively prevent cervical cancer. Therefore, it is essential to evaluate the prevalence of HPV types. Aim: To evaluate the incidence of HPV infection in a university hospital in Cheonan, Korea over 5 years and its changes over time. Materials and Methods: This was a retrospective study. HPV detection and genotyping were performed on 7,874 consecutive cervical swab specimens between 2013 and 2018. Cervical swab specimens were obtained from women aged 21-81 years using a cervical brush and specimen transport medium. HPV DNA was detected by multiplex real-time PCR. The detected HPV types were classified according to risk. HPV data were analysed using R. (version 3.3.3, Comprehensive R Archive Network; https://www.r-project.org) The chi-square test was performed to analyse categorical data. The prevalence and 95% confidence intervals were calculated for the overall HPV genotypes and each individual genotype. Statistical significance was considered at p<0.05. Results: The positive detection rate was 18.5%. The average age of all the patients was 38.6±8.55 years, and the most commonly detected virus types were Types 52 (n=223), 68 (n=185), and 39 (n=154). Among the positive specimens, 70.4% were single infections and 30.6% were multiple infections. The ratio of multiple to single infections for various age groups was 49.7% for patients in their twenties and 31.0% for those in their sixties. Conclusion: The incidence of HPV infections and the average age of infected patients were similar to the global averages. While Types 16 and 18 are frequently detected in the international community, Type 52 was particularly unique in the present study. The high incidence of HPV infection and high frequency of multiple infections observed in the present study highlight the need for intensive management in young women.
Authors and Affiliations
Jae-Sik Jeon, Jae Kyung Kim
Keywords
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- EP ID EP639665
- DOI 10.7860/JCDR/2019/41904.13052
- Views 125
- Downloads 0
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