One-pot, four component synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines derivatives
Journal Title: Asian Journal of Green Chemistry - Year 2018, Vol 2, Issue 4
Abstract
A green approach to synthesis of the polyfunctionalized pyrazole [4′,3′:5,6]pyrido[2,3-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA (Triethylamine) as a catalyst in water under the reflux conditions. This protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities.
Authors and Affiliations
Ramin Javahershenas, Jabbar Khalafy
Keywords
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- EP ID EP468809
- DOI 10.22034/ajgc.2018.62714
- Views 80
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