One-pot synthesis of ferrocene-containing 1,3,4-oxadiazole derivatives from N-isocyaniminotriphenylphosphorane (Ph3PNNC), cyclic ketones and ferrocene carboxylic acid
Journal Title: Eurasian Chemical Communications - Year 2019, Vol 1, Issue 0
Abstract
Reactions of N-isocyaniminotriphenylphosphorane with a cyclic ketone in the presence of ferrocene carboxylic acid proceeded smoothly at room temperature and in neutral conditions to afford ferrocene-containing 1,3,4-oxadiazole derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed. The structures of the products were deduced from their IR, 1HNMR, and 13CNMR spectra. The method offers a mild, simple, and efficient route for the preparation oreaction of N-isocyaniminotriphenylphosphorane with cyclic ketones in the presence of ferrocene carboxylic acid proceeded smoothly at room temperature and in neutral conditions to afford ferrocene-containing 1,3,4-oxadiazole derivatives in high yields. The reaction proceeded smoothly and cleanly under mild conditions and no side reactions were observed. The structures of the products were deduced from their IR, 1HNMR, and 13CNMR spectra. f sterically congested ferrocene-containing 1,3,4-oxadiazole derivatives from cyclic ketones, N-isocyaniminotriphenylphosphorane (Ph3PNNC) and ferrocene carboxylic acid. Its ease of workup, high yields and fairy mild reaction conditions make it a useful addition to modern synthetic methodologies.
Authors and Affiliations
Mona Ashtary, Ali Ramazani, Morteza Rouhani
Keywords
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- EP ID EP658082
- DOI 10.33945/SAMI/ECC.2019.1.11
- Views 215
- Downloads 0
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