Open Labelled Pilot Study of Topically Applied Curcumin Versus Standard Treatment on Chronic Wound Healing
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 10
Abstract
Introduction: Failure of the timely and orderly reparative process to establish the anatomic and functional integrity results in chronic wound. Inflammation is essential for normal wound healing, but an unchecked inflammation hampers the healing process. Any agent that effectively reduce excess inflammation can be useful in wound healing. The objectives of this study were to evaluate the efficacy of topical curcumin in healing of the chronic wounds and also to study its effect on NF- kB and COX-II expression levels in chronic wound tissues compared to controls receiving standard treatment. Material and Methods: This is a pilot study conducted in 20 patients with chronic ulcer, divided into two equal groups. A comparision was done between two groups who were treated with topically applied curcumin ointment versus our standard treatment protocol for wound management. All these patients were evaluated clinically, qunatitative bacterial culture and expression of molecular markers in the wound. Results: The efficacy of curcumin on wound contraction rate, accrural of granulation tissue, epithelizartion and reduction in bacterial colony count was not statistically significant compared to standard treatment protocol. Expression levels of proinflammatory genes mainly COX-2, TNF-α, IL-6, IL-1b was reduced and NF-κB translocation into the nucleus was also inhibited in curcumin treated group compared to standard treatment protocol. Conclusion: Although there was no difference in both the groups in its clinical parameters, curcumin treated group showed underexpression of pro-inflammatory genes and inhibition of translocation of NF-κB which have a barrier role on the excess inflammation. This favours the positive role of curcumin on treating the chronic wounds.
Authors and Affiliations
Kiran Jayaprasad, Janarthanan Ramu, Subramania Iyer, Kamath C R, Arun Pattatheyil
Keywords
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