Opening the Microcirculation with Ketanserin I.V. Improves Peripheral Temperature: An Observational Cohort Study
Journal Title: Enliven: Journal of Anesthesiology and Critical Care Medicine - Year 2017, Vol 4, Issue 1
Abstract
Objectives Skin mottling and an increased delta temperature (deltaT) between core and peripheral sides as measurements of microcirculatory dysfunction are associated with increased mortality in intensive care patients. We studied the effect on deltaT of ketanserin, a 5-HT2 receptor-blocking agent. Methods A retrospective analysis was performed of all intensive care patients that received ketanserin by continuous infusion. Over four to eight consecutive hours the change in deltaT (forefoot) was determined. To exclude lead-time bias we compared with a three-hour period before the start of ketanserin. Results 1875 consecutive patients received a mean total dose of 225 (SD 110) μg/kg/min ketanserini.v. The peripheral temperature rose mean 2.6°C over eight hours and delta T declined mean 2.4°C. A repeated measures analysis showed a significant rise in peripheral temperature. Comparing three hours before with three hours after start of ketanserin, all other parameters did not significantly change. Conclusion The microcirculation measured as peripheral temperature of critically ill patients, significantly improved with a continuous infusion of ketanserin. This increase is not associated with hypotension or the need of vasoconstrictors.
Authors and Affiliations
Van der Voort Peter HJ, Bosman Rob J, Franssen Eric JF, Rijkenberg Saskia
Keywords
Related Articles
- EP ID EP626108
- DOI -
- Views 166
- Downloads 0
Left Ventricular Assist Device and Resident Cardiac Stem Cells in Heart Failure: Human Heart's Potential Matter
Heart disease is the leading cause of mortality in Western countries, accounting for 17.3 million deaths per year. The impact of cardiovascular diseases is influenced by the ability to treat and assist patients surviving...
Patient with Eisenmenger's Syndrome and Severe Progressive Kyphoscoliosis presents for Posterior spinal fusion
A fourteen year old male patient with Eisenmenger’s syndrome (ES) and severe, progressive kyphoscoliosis presented for posterior spinal fusion, T2-L2. A thorough, preoperative evaluation and multidisciplinary conference...
Bacterial Colonization and Infection Rate of Epidural Catheters used for Postoperative Analgesia
Background & Aim Epidural analgesia is one of the commonest modes for providing postoperative analgesia after surgery and epidural space infection is a major concern despite low incidence. We prospectively studied the in...
Lactic Acidosis during Anesthesia for Glioblastoma Multiforme Resection: The Warburg Effect
Background: The purpose of this case report is to present a case of significant lactic acidosis without clinical evidence of hypoperfusion, and show that it is likely due to lactic acid production by the brain tumor glio...
Support Vector Machines and Relevance Vector Machines and Their Usage
The researchers sought to use to supervised machine learning algorithms to determine the minor set of genes that can provide exact cancer from the microarray data. The importance of getting the minimum subset significant...