OPTIMIZATION OF CULTURE CONDITIONS OF STREPTOMYCES CARPATICUS (MTCC-11062) FOR THE PRODUCTION OF ANTIMICROBIAL COMPOUND
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: To improve the antimicrobial compound productivity of Streptomyces carpaticus (MTCC-11062) by optimizing its physical and chemical parametersMethods: Streptomyces carpaticus (MTCC-11062) was isolated from Visakhapatnam sea coast of Bay of Bengal and was screened for its antimicrobial activity by using agar well diffusion method. To improve the production of antimicrobial compound the medium composition and physical parameters were optimized and its productivity was studied against Bacillus cereus (MTCC 430) Escherichia coli (MTCC 443), Candida albicans (MTCC 227) obtained from MTCC, Chandigarh, India.Results: Optimum growth of mycelium and antimicrobial compound production occurred at pH 7.2, agitation 180 rpm and temperature 300C with glucose 10g/L, soyabean meal 2.5g/L, K2HPO4 2g/L, MgSO4 1g/L, NaCl 7.5g/L and trace salts.Conclusion: The optimization of cultural conditions proposed in this paper has effetely improved the antimicrobial compound productivity of Streptomyces carpaticus (MTCC-11062).
Authors and Affiliations
M Bhavana, Vssl Prasad Talluri, K Shiva Kumar, S. V. Rajagopal
Keywords
Related Articles
- EP ID EP579706
- DOI -
- Views 59
- Downloads 0
COMPARATIVE PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDY OF VARIOUS SPECIES OF THE CONTROVERSIAL DRUG ‘PUNARNAVA'
Objective: Punarnava is a controversial drug i.e. its true botanical identity has not been ascertained, and several different species are used as Punarnava. It is a part of many medicinally important traditional formulat...
APPLE PECTIN (AP) INDUCED APOPTOSIS VIA NITRIC OXIDE (NO) IN HUMAN PROSTATE CANCER CELLS DU145
Objective: Apoptosis or programmed cell death is a physiological process in which cells die. Many cancer chemical drugs induce apoptosis to omit cancer cells. Since prostate cancer is one of the most common cancers among...
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR QUANTITATIVE ESTIMATION OF NIMBOLIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Objective: The present study was aimed to a simple, new, rapid and highly sensitive Reverse Phase - High Performance Liquid Chromatographic (RP-HPLC) method has been developed and an assay was validated for the quantitat...
DEVELOPMENT OF CASHEW GUM AND ITS DERIVATIVES FOR SUSTAINED RELEASED DRUG DELIVERY SYSTEM: BY RESPONSE SURFACE METHODOLOGY
The aim of the present study was to investigate the Cashew gum (CG) and its modifications for formulating the sustained release delivery system using theophylline (TH) as a model drug by varying the gum to drug ratio (1:...
PROTEOMIC ANALYSIS OF HUMAN BLOOD AND URINE IN DIABETIC NEPHROPATHY
Objective: To investigate the proteomics status of human blood and urine in diabetic nephropathy.Methods: In the present study 90 patients were selected. The study was comprised of 30 Diabetic mellitus (DM) with microalb...