OPTIMIZATION OF EXTRACTION PARAMETERS FOR TOTAL FLAVONOIDS FROM GARDENIA GUMMIFERA GUM RESIN BY RESPONSE SURFACE METHODOLOGY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 11
Abstract
Objective: To optimize the extraction parameters for determining the highest yield of Total Flavonoids from Gardenia gummifera gum resin.Methods: In the present study, response surface methodology (RSM) with three level Box Behenken design (BBD) was performed to optimize extraction parameters for total flavonoids. Solvent concentration(A), extraction time (B) and extraction temperature(C) were considered for single factor experiment.Results: The highest flavonoid concentration was obtained with acetone 45.00% v/v, time 101.46 min, temperature 41.57 °C. The average experimental TFC under optimal conditions was 161.14 mg/g which was in close agreement with the predicted value of 163.42 mg/g.Conclusion: RSM-BBD is successfully applied in optimizing extraction conditions for extraction of total flavonoids from G. gummifera gum resin.
Authors and Affiliations
Snehal B. Bhandare, Kirti S. Laddha
Keywords
Related Articles
- EP ID EP575883
- DOI 10.22159/ijpps.2016v8i11.11134
- Views 71
- Downloads 0
THE PHARMACOLOGICAL EFFECT OF STILBENES ISOLATED FROM KANGAROO ISLAND PROPOLIS ON SIRT-1 ENZYME ACTIVITY
Objective: Resveratrol, a trihydroxystilbene, has been claimed to be a potent activator to SIRT-1 enzyme activity, which in turn could have a useful future application in the management of many chronic conditions such as...
FORMULATION, DEVELOPMENT AND IN VITRO EVALUATION OF TRAMADOL EXTENDED RELEASE TABLETS
Objective: The objective of the present study was to develop “once daily” extended release tablets of tramadol (100 mg) by wet granulation using hydrophilic polymer like hydroxy propyl methyl cellulose K100M,K15M and pol...
IN VITRO DPPH RADICAL SCAVENGING AND ANTI-BACTERIAL ACTIVITY OF OMAN’S CYMBOPOGON
Objective: The objective of this work is to evaluate antioxidant and anti-microbial activity of methanolic extract of Omani Cymbopogan schoenanthus.Methods: Antibacterial activity of mehanolic extract of Cymbopogan was e...
EVOLUTION OF NANOTECH ASSISTED PCR DIAGNOSIS OF MYCOBACTERIUM TUBERCULOSIS AND ITS ASSESSMENT WITH CONVENTIONAL METHODS
Objective: This study was focused on assessment and performance of conventional and nanotech assisted methods for detection of Mycobacterium tuberculosis. Tuberculosis (TB) still leftovers one of the top ten causes of de...
POLYMERIC NANOPARTICLES FOR IMPROVED BIOAVAILABILITY OF CILNIDIPINE
Objective: In the present study, we aimed to optimize, characterize and evaluate poly lactic-glycolic acid nanoparticles of cilnidipine for improved permeation across the gastrointestinal tract.Methods: Poly lactic-glyco...