Optimization of somatotropin dose during treatment of children before puberty with the syndrome of bioinactive growth hormone
Journal Title: Український журнал дитячої ендокринології - Year 2018, Vol 0, Issue 1
Abstract
Objective — to study effectiveness and safety of applying various doses of recombinant growth hormone (rGH) during treatment of children before puberty with the syndrome of bioinactive growth hormone (SBGH) in order to improve their eventual growth. Materials and methods. We have examined 93 children before puberty, aged 3 to 10 years, afflicted with SBGH. In all children there has been found a growth retardation exceeding 2 standard deviations (SD) from physiological parameters. For the purpose of differential diagnostics of SBGH and determination of sensitivity to rGH we were using fourday test with growth hormone. Treatment of all patients with rGH begun with a 0.03 mg/kg/day dose. The control group consisted of 48 children before puberty with pituitary dwarfism. Results and discussion. In the main group we identified smaller growth effect than in the control group. Significant difference between growth gain in the main group and in the control group was determined since 6th month of rGH treatment and was there until the end of 12th month in case of hormone usage. In children with unsatisfactory growth gain the rGH dose was increased to 0.035 mg/kg/day; in case of further insufficiency of growth rate the rGH dose was increased to 0.05 mg/kg/day. After 12 months of treatment with various doses of rGH the optimal growth effect has been achieved in the subgroup of children with an rGH dose of 0.05 mg/kg/day. Conclusions. Optimally the treatment of patients with SBGH should be started with rGH dose of 0.035 mg/kg/day; in case of unsatisfactory effect after 3–6 months it is recommended to increase rGH dose to 0.05 mg/kg/day.
Authors and Affiliations
N. A. Sprynchuk, Yu. I. Belyakova
Keywords
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