OPTIMIZING NASAL FOROPTIMIZING NASAL FORMULATION FOR PREVENTION OF SERIOUS INFECTIONS CAUSED BY MRSAMULATION FOR PREVENTION OF SERIOUS INFECTIONS CAUSED BY MRSA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 1
Abstract
Objective: Lyophilized nasal insert formulations containing 2% mupirocin which is an antibiotic used to prevent serious infections caused by meticillin resistant Staphylococcus aureus (MRSA) pathogen were prepared.Methods: Different grades of methylcellulose (MC) polymerwere used to prepare mupirocin nasal inserts using aqueous (water) and organic (tertiary butyl alcohol) methods. Dynamic adhesion, drug release profile and antibiotic sensitivity studies were undertaken to evaluate the performance of the nasal inserts in comparison to Bactroban nasal ointment.Results: The results showed that each grade of MC polymer has different adhesion properties. In organic prepared formulations,the solution form of mupirocin in tertiary butyl alcohol resulted in a significant increase in the adhesion of these formulations in comparison with blank formulations. On the other hand, mupirocin suspended in aqueous solvent (water) had little effect. However both aqueous and organic prepared formulations resulted higher adhesion performance when compared to Bactroban nasal ointment. The drug release of incorporated mupirocin from MC matrix of organic prepared formulations after 180 minuteswas slower (11.9-12.5%) than mupirocin from aqueous prepared formulations (85.6-88.4%). while, the maximum percent of mupirocin releasedfrom Bactroban nasal ointment was just 4% after the same time.Conclusion: The growth inhibition of Staphylococcus aureus pathogen obtained by using lyophilized nasal insert formulationwhich contained Mupirocin was very active. Thus, the nasal insert is promising in treatment of nasal colonizedby MRSA.Â
Authors and Affiliations
Issam Yasser Husean, Issraa Rasheed Abed Al-rahman Al-obaidi
Keywords
Related Articles
- EP ID EP579243
- DOI -
- Views 73
- Downloads 0
COMPARATIVE EVALUATION OF ANTIDIABETIC AND ANTIOXIDANT POTENCY OF DIFFERENT EXTRACTS OBTAINED FROM MEMECYLON SPECIES
Objective: Memecylon species is being extensively used in traditional medicine for the treatment of skin disorders and it is proved to possess antidiabetic and anti-inflammatory properties. The present investigation was...
THE EFFECT OF INDONESIAN VELVET BEAN EXTRACT ON THE FERTILITY OF ALBINO MALE MICE
Objective: This research aims to determine the dose of Indonesian velvet bean (Mucuna pruriens) extract which has significant effect on the ferlitity mice (concentration, motility and morphology of mice sperm). The extra...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL STUDIES OF PIPER BETLE LINN.LEAF
Objective: The present work has been done to establish various pharmacognostical, physicochemical and phytochemical parameters of the leaf of Piper betle Linn. (Bangla variety) belonging to family Piperaceae. This could...
FISHBURNE’s METHOD AND THE CLASSICAL METHOD OF PHARMACOECONOMIC ANALYSIS IN THE EVALUATION OF ANTIBIOTIC TREATMENT OF ACUTE AND RECURRENT BRONCHITIS IN CHILDREN
Objective: This study was performed in order to estimate clinical effectiveness of antibiotic therapy in acute and recurrent obstructive bronchitis. For estimation the following was used: the Fishbern method of antibioti...
DEVELOPMENT AND VALIDATION OF A DRIED BLOOD SPOT LC-MS/MS ASSAY TO QUANTIFY GEMCITABINE IN HUMAN WHOLE BLOOD: A COMPARISION WITH AND WITHOUT CYTIDINE DEAMINASE INHIBITOR
Objective: The purpose of this paper is to develop and validate a LC-MS/MS method for the quantification of gemcitabine in whole human blood using dried blood spots.Methods: Gemcitabine fortified blood samples without te...