STABILITY INDICATING RP HPLC METHOD FOR THE ESTIMATION OF ARMODAFINIL IN TABLET DOSAGE FORM
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 8
Abstract
Objective: To develop simple reverse phase HPLC method for the estimation of Armodafinil in tablet dosage form.Methods: Chromatography was performed by isocratic elution on a Stainless steel Hibar C18 column with dimensions 4.6 x 250 mm, packed with octadecylsilane bonded to porous silica (C18) with particle size 5 micron. Acetonitrile and water in the ratio of 50:50 v/v is used as mobile phase. The flow rate is 1.0 ml/ min and effluent is monitored at 220 nm. Armodafinil was eluted at a retention time of 3.8 minutes.Results: The standard curve of Armodafinil was linear over a working range of 1–700 µg/ml and gave an average correlation coefficient of 0.999. The limit of quantitation (LOQ) of the drug is 0.1 µg/ ml. Recovery studies were carried out by standard addition method and the recoveries are found satisfactory within the range of 99.3 to 101.5 %. The method is precise with % RSD belowConclusion: The method is validated in terms of robustness and forced degradation studies were carried out and this method can be applied for routine degradation studies ans quantification in regular laboratories.
Authors and Affiliations
P Vivek Sagar, Nelofer Bagum, S. Shobha Rani
Keywords
Related Articles
- EP ID EP579781
- DOI -
- Views 108
- Downloads 0
FORMULATION AND EVALUATION OF GLIPIZIDE MICROEMULSION
Objective: The aim of the present study was to formulate a microemulsion for the oral delivery of Glipizide.Methods: Microemulsion systems composed of oleic acid, isopropyl myristate as oils; tween 80, span 20 and cremop...
VASCULAR ENDOTHELIAL GROWTH FACTOR VEGF G/C 405 AND C/A 2578 GENE POLYMORPHISMS IN CASES WITH PRE-ECLAMPSIA
Vascular endothelial growth factor gene plays a crucial role in physiological vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia (PE). VEGF's normal function is to creat...
EXTEMPORANEOUS COMPOUNDING PRACTICE BY PHARMACISTS: A SYSTEMATIC REVIEW
Objective: To identify the frequency and scope of extemporaneous compounding practice reported in community and hospital pharmacies.Methods: A systematic literature review was undertaken to identify the prevalence of ext...
SYNTHESIS, REACTIVITY AND BIOLOGICAL EVALUATION OF TRIAZOLE: RECENT DEVELOPMENTS
This review summarizes the synthetic methods, reactions and biological applications of pharmacological important 1, 2, 4-triazole isomer and recent developments in their derivatives such as Mannich base, Schiff’s base,...
MESUAFERRIN A-BIOACTIVE FLAVONOID ISOLATED FROM THE BARK OF MESUA FERREA L. AGAINST PHOSPHOLIPASE A2, CYCLOOXYGENASE AND LIPOXYGENASE: AN IN VITRO, IN VIVO AND IN SILICO APPROACH
Objective: The main objective of the present study was to evaluate the anti-inflammatory activity of isolated bioactive flavonoid Mesuaferrin-A from the bark of Mesuaferrea L. by in vitro, in vivo and in silico approach....