ORAL ACUTE TOXICITY STUDIES ON ACTION BITTERS IN ALBINO RATS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 12
Abstract
In this work, the oral acute toxicity profile of Action bitters in albino rats was studied. The studies were conducted in two phases, phase one (1) and phase two (2). A total number of twenty one (21) albino rats were used. These were randomly distributed into seven groups. Group one (1) to four were used in phase 1 while group five (5) to seven (7) were used in phase two. In phase 1 study, the first group were administered with distilled water and used as control while groups two to four were treated with 2, 4, and 6 ml/kg b. w of the Action bitters respectively. All animals were observed for the first twenty four hours for toxicity signs and mortality. From the result obtained, the doses of the action bitters were increased to 12, 16 and 20 ml/kg b. w in phase 2. At the end of 24 hours, toxicity and mortality were also recorded. All animals were observed for 72 hours at the end of which they were sacrificed. Blood samples were taken for the determination of haemoglobin (Hb) level and Packed cell volume (PCV). Results showed that at maximum dose, 20ml/kg b. w (phase 2), only shivering and paw licking were observed without death occurring. There were also slight changes in body weight of the animals. Results of the haematological analysis revealed significant reduction (P<0.05) in both Hb and PCV. It was thus concluded that the median lethal dose (LD50) of action bitters in albino rats lies within a range above 20ml/kg b. w.
Authors and Affiliations
Abiodun I. K.
Keywords
Related Articles
- EP ID EP627700
- DOI -
- Views 138
- Downloads 0
COMPARATIVE STUDIES OF ANTIMICROBIAL PROPERTIES OF BRYOPHYLLUM PINNATUM AND CITRUS LEMON ON PATHOGENIC BACTERIA ISOLATES.
Antimicrobial activities of Bryophyllum pinnatum and Lemon Juice extract against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were investigated. Blanched and ethanol extract of the leaves of Bryophy...
HEALTH BEHAVIOR CHANGE IN PREGNANT WOMEN WITH OBESITY
Maintaining levels of physical activity, eating a healthy diet and weight management are important health behaviors for pregnant women and their unborn child. This study indicates that pregnancy provides an opportunity f...
CHARACTERIZATION OF THE COMBINATION OF CHONDROTIN SULFATE, CHITOSAN AND KAPPA CARERGEENAN USING THE IONIC GELATION METHOD FOR PAINFUL KNEE OSTEOARTHRITIS
Objective: Application of the use of chondroitin sulfate as an alternative medicine in addition to nonsteroidal antiinflammatory drugs has the ability to inhibit the development of osteoarthritis. The use of chondroitin...
POTENTIAL AND COMPARATIVE TESTS OF CEFADROXILE ANTIBIOTICS AS EVALUATION OF THE QUALITY OF ANTIBIOTICS IN CASES OF ANTIBIOTIC RESISTANCE
Objective: Acute Respiratory Infection (ARI) is an acute infection of any part of the respiratory tract including the paranasal sinuses, middle ear, and pleural cavity. Cefadroxile antibiotics are one of the antibiotics...
MEASUREMENTS OF HEAD CIRCUMFERENCE, INTERCANTHAL DISTANCES, CANTHAL INDEX AND CIRCUMFERENCE INTERORBITAL INDEX OF CHILDREN AND ADOLESCENTS IN BAYELSA STATE IN NIGERIA.
The study was carried out to determine standard values for head circumference, inner canthal distance, outer canthal distance, canthal index and circumference interorbital index of children and adolescents in the four et...