Oral Administration of Menthol Alleviate Adverse Effects of Polycystic Ovarian Syndrome in Blood Biochemical Parameters and Antioxidant Status in Wister Rats.
Journal Title: GMJ Medicine - Year 2017, Vol 1, Issue 1
Abstract
Background: Polycystic ovarian syndrome (PCOS) has been related to dyslipidemia and suppression of antioxidant status. Howeverl, novel agents such as menthol can be an efficient strategy for alleviation of PCOS. This study was conducted to evaluate the effects of different levels of menthol in blood biochemical parameters and antioxidant status in Wistar rats induced with PCOS. Methods: Fifty Wistar rats were used in this study and the animals divided into five groups including; 1) Control group (Control) or healthy rats, 2) PCOS group (PCOS) that did not receive any menthol, 3, 4 & 5) Animals that received 2, 4 and 6 mg/kg of body weight (PCOS-2, PCOS-4 and PCOS-6). To induce the PCOS, 5 mg estradiol valerate was administrated. At the end of the trial session, blood samples were taken to evaluate plasma concentrations of glucose, insulin, total cholesterol, triglycerides, HDL-C, LDL-C, ferric-reducing ability of plasma (FRAP), advanced oxidation protein product (AOPP) and total oxidation status (TOS). Results: Induction of PCOS increased glucose, insulin, total cholesterol, triglycerides, LDL-C, FRAP, AOPP and TOS, and decrease HDL-C. The use of menthol especially in higher levels improved the mentioned parameters. PCOS also increased body weight and oral treatment of menthol helped to maintain the body weight. Conclusion: It is concluded that menthol improved antioxidant status in rats with PCOS. Thus, use of menthol is recommended for treatment of PCOS.
Authors and Affiliations
Behzad Mesbahzadeh, Mahshid Garmsiri, Faranak Jalalvand, Layla Shojaie, Muhammad Azam Kakar
Keywords
Related Articles
- EP ID EP44537
- DOI -
- Views 455
- Downloads 0
Beneficial Effects of Curcuminon on Rats with Polycystic Ovary Syndrome: Evaluation of the Gene Expression of GLUT4, ErĪ± and Insulin Resistance
Background and purpose: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in the women and animals. Some common hormonal therapies are used to treat the PCOS condition. This study was cond...
Dietary Supplementing with Resveratrol Improves Antioxidant Status in Hypercholestrolemic Rats
Background and purpose: Natural agents have been used for protection against damages. This study was conducted to evaluate the effects of dietary supplementing of resveratrol on antioxidant status improvement in hyper...
Relation Between Novel Markers with Sperm Quality in Obese Rats
Background: Obesity and inflammation stemmed from obesity basically affects fertility and male reproductive system by its negative effect on erectile dysfunction and semen variables. Novel factors could be used to determ...
The Effect of Cigarette Smoking on Lung Capacity in Active, Previous, and Passive student smokers
Background: Cigarette smoke predisposes a person to a lot of preventable diseases; this study aimed at comparing Lung Function in active, previous and non-smokers in students using the ratio of Forced Vital Capacity, to...
Original Article: Anthropometric Study of the Facial Index in the Population of Medical Students in Tehran University of Medical Sciences
Background: Facial anthropometry is useful in individual identifcation and reconsructive surgery. In the present sudy, we aimed to determine the facial characterisic of the Iranian population through anthropometric sud...