Oral administration of monosodium glutamate alters growth and blood parameters in female rabbits
Journal Title: European Journal of Biological Research - Year 2016, Vol 6, Issue 3
Abstract
Thirty-two female rabbits were used to evaluate the impact of varied doses of aqueous solution of monosodium glutamate (MSG) - a food additive, on growth performance and blood parameters in cross-bred rabbits. The rabbits were randomly assigned into four groups of eight rabbits each. Group 1 received no MSG, group 2 received 1 mg, group 3 received 2 mg, and group 4 received 4 mg per kg body weight of 40% aqueous solution of MSG every 48 hrs for nine weeks, constituting the control, low, medium and high dose groups, respectively. At the end of nine weeks of MSG administration, blood samples were obtained from 16 rabbits, consisting of four from each group for haematological and serum biochemical analyses. The mean feed intake and final weights gained by the rabbits significantly (p<0.05) increased with increased doses of MSG administered. The mean white blood cell values of those administered aqueous MSG were generally higher than those of the control, while significant reduction in the serum proteins of rabbits administered with MSG compared to the control was observed. The serum activities of AST and ALP as well as the cholesterol levels of rabbits administered 2 and 4 mg MSG/kg body weight were significantly higher (p<0.05) than those on control and low dose MSG. This study has shown that MSG, even at low doses, is capable of producing alterations in the body weight. The consumption of MSG should be reconsidered taking into account its hepatotoxic and dyslipidaemia effects.
Authors and Affiliations
Francis Ayodeji Gbore, Olubu R. Olumomi, Irewole M. Aworetan, Ruth A. O. Gabriel-Ajobiewe
Keywords
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- EP ID EP230388
- DOI 10.5281/zenodo.150297
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