ORAL CONTRACEPTIVES AS A RISK FACTOR FOR DEVELOPING BREAST CANCER IN BREAST CANCER (BRCA) GENE CARRIER FEMALE IN- THE 30-60 YEARS AGE GROUP: A META ANALYSIS
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 1
Abstract
The literature linking breast cancer with oral contraceptives and BRCA mutation as possible risk factors is equivocal. Hence, to account for these conflicting results in the existing literature and to observe the net effect, this meta-analysis aims to investigate whether oral contraceptives are a risk factor for developing breast cancer in breast cancer (BRCA) gene carrier female in the 30-60 years age group. Method: Systematic review of the literature, both published and unpublished, and meta-analysis of relevant data. Results: Meta-analysis of data from five relevant studies, with a total of 6682 BRCA carriers (3,269 BRCA1 carriers and 791 BRCA2 carriers), revealed that use of oral contraceptives is associated with increased risk of breast cancer among BRCA mutation carriers (OR=2.267; 95 % CI= 1.311, 3.919). When the same risk was stratified by mutation type, both BRCA1 and BRCA2 were at increased risk. However, BRCA2 carriers (OR= 3.060; 95% CI=0.951, 9.848) were found to be at elevated risk compared to BRCA1 carriers (OR= 2.347; 95% CI=0.939, 5.865). Conclusions: This metaanalytical finding suggests that oral contraceptives are a risk factor for developing breast cancer in breast cancer (BRCA) gene carrier females.
Authors and Affiliations
Ghimire S| Department of Public Health, Valley College of Technical Sciences (VCTS), Kathmandu, Nepal, Corresponding author email: sarunaghimire@gmail.com, Shrestha N| Department of Public Health, Valley College of Technical Sciences (VCTS), Kathmandu, Nepal, BK Baral| Department of Biochemistry, Nepal Medical College & Teaching Hospital (NMCTH), Kathmandu, Nepal
Keywords
Related Articles
- EP ID EP11356
- DOI 10.5958/2319-5886.2015.00022.3
- Views 300
- Downloads 13
OUTCOME OF INTERTROCHANTERIC FRACTURES TREATED WITH SHORT FEMORAL NAIL
Aim: To study the functional and anatomical outcome of Inter trochanteric fractures of femur treated with Short femoral nail. Method: This was retrospective study carried out in which 60 patients (50 Male & 10 Female) o...
Mandibular Ramus Notching As a Tool for Sexual Dimorphism
Sex determination from a single or a part of bone is always difficult in absence of other bones of the same individual. The current study is an attempt to know the sex of an individual from the study of posterior ramus...
Prediction of Marital Dissatisfaction Based on Personality Characteristics and Social Relations in Couples of Students and Non-Students
Te aim of this research was to study the prediction of marital dissatisfaction based on personality characteristics and social relations in couples of students and non-students. For this purpose, using Cluster sampling,...
The healing effect of combined hydroalcoholic extract of Teocurium polium and the seed hull of Quercus brantii on burn wounds in rats
Plants and their extracts have considerable potential for wound healing. So, The aim of this study was to evaluate the wound healing effect of combined hydroalcoholic extract of Teocurium Polium (TP) and the seed hull o...
Sero- Epidemiological trends of Dengue Fever in Jammu Province of J&K State
Dengue, an arthropod-borne arboviral disease is becoming a major public health concern, both in the tropical and subtropical regions of the world. In view of exponential increase in dengue positive cases reported in 201...