The healing effect of combined hydroalcoholic extract of Teocurium polium and the seed hull of Quercus brantii on burn wounds in rats
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 10
Abstract
Plants and their extracts have considerable potential for wound healing. So, The aim of this study was to evaluate the wound healing effect of combined hydroalcoholic extract of Teocurium Polium (TP) and the seed hull of Quercus brantii (Persian oak) (QB) and comparing with silver sulfadiazine (SSD) ointment (1%) in rats. Animals were divided into six groups consist of normal (untreated), physiologic serum, TP, seed hulls of Quercus brantii (QB), combination of TP and QB and the other group was SSD. Burn area size, epidermal and dermal diameter, number of hair follicle, histopathology of the burn skin and concentration of plasma malondialdehide (MDA) were determined in different groups. Animals treated with QB and TP, SSD and combination of two extracts (QB +TP) showed a significant reduction in the burn area. Serum MDA decreased significantly in animals treated with QB, TP and QB+TP. Histological comparison has shown that TP, QB and combination of them significantly increased reepithelialization in burn wounds, as compared to normal group. In conclusion, our results demonstrated that topical application of TP and QB has a significant effect on the burn wound healing.
Authors and Affiliations
Mohammadi Jamshid| Associate Professor of Physiology, Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran, Nikbakht Jafar| Assistant professor of Pharmacology, Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran, Mohammadi Bahram| Assistant professor of pediatrics, Department of pediatrics, Medicine School, Yasuj University of Medical Sciences, Yasuj, Iran, Jafari Barmak Mehrzad| Assistant professor of histology, Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran, Vafaienejad Tahereh| Student of nutrition , Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran, Talebianpoor Mohammad Sharif| Assistant professor of Pharmacology, Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran Corresponding E-mail: Taleb_84@yahoo.com
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