ORAL DISINTEGRATING TABLETS(ODTS): A REVIEW
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 7
Abstract
Recently ODT terminology has been approved by United States Pharmacopoeia, British Pharmacopoeia, and Centre for Drug Evaluation and Research (CDER). US FDA defined ODT tablets as “A solid dosage form containing medicinal substances which disintegrates rapidly usually within a matter of seconds, when placed upon the tongue. The newest generation of ODTs can produce more robust, versatile tablets that overcome some of the limitations of earlier ODTs. The performance of ODTs depends on the manufacturing technology and the most necessary property of such a dosage form is the ability of rapidly disintegrating and dispersing or dissolving in the saliva, thereby obviating the need for water intake. Disintegrates are substances or mixture of substances added the drug to the formulation that facilitates the breakup or disintegration of tablets or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrates. Examples of superdisintegrants are croscarmellose, crosspovidone, sodium starch glycolate which represent example of cross linked cellulose.
Authors and Affiliations
Haritha Pasupulati
Keywords
Related Articles
- EP ID EP671084
- DOI -
- Views 170
- Downloads 0
YASHTIMADHU (GLYCYRRHIZA GLABRA LINN.) A REVIEW
Yashtimadhu is an important plant in Indian medicinal plant. A genus of perennial herbs and under shrubs distributed in the sub-tropical and warm temperate regions of the world, chiefly grown in the mediterian countries...
CARBAPENEM RESISTANCE-DETERMINING GENES AMONG MULTI-DRUG RESISTANT BACTERIAL ISOLATED FROM CLINICAL SAMPLES IN BASRAH GOVERNORATE
Increasing resistance to carbapenems, may significantly reduce the choice of effective antibiotics. This study was conducted to determine the occurrence of carbapenmase producing bacteria isolates obtained from Basrah ho...
VERY-LOW-CARBOHYDRATE HYPOCALORIC DIET AND COFFEE INTAKE EXHIBIT ADDITIVE AND REINFORCING EFFECTS IN PREVENTION AND REVERSAL OF TYPE 2 DIABETES MELLITUS: PRELIMINARY EVIDENCE
Increasing sedentary lifestyles fuel the rising incidence of type 2 diabetes mellitus, a major risk factor for memory loss, kidney failure and stroke. Of all dietary manipulations, only the hypocaloric intervention has a...
THE FREQUENCY OF ABO BLOOD GROUPING AND RHESUS ANTIGENS AMONG SUDANESE BLOOD DONORS
Back Ground: ABO and Rhesus (Rh) blood group antigens are hereditary characters and are useful in population genetic studies, resolving medico-legal issues and more importantly in pre-transfusion testing in blood banking...
RELATIONSHIP BETWEEN TONSILLITIS AND COLONIZATION OF HELICOBACTER PYLORI IN TONSILLAR TISSUE
Aim: The aim of the current study is to investigate whether tonsillar tissue of patients with tonsillitis plays a reservoir role for Helicobacter pylori (H. pylori). Background: Recently, there have been arguments regard...