VERY-LOW-CARBOHYDRATE HYPOCALORIC DIET AND COFFEE INTAKE EXHIBIT ADDITIVE AND REINFORCING EFFECTS IN PREVENTION AND REVERSAL OF TYPE 2 DIABETES MELLITUS: PRELIMINARY EVIDENCE
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2017, Vol 4, Issue 5
Abstract
Increasing sedentary lifestyles fuel the rising incidence of type 2 diabetes mellitus, a major risk factor for memory loss, kidney failure and stroke. Of all dietary manipulations, only the hypocaloric intervention has acquitted itself as a credible and potent tool for the prevention and reversal of type 2 diabetes mellitus. Dietary lifestyle intervention or calorie restriction-mimetics have shown great promise in reversing omics signatures to normal in type 2 diabetes mellitus, dyslipidaemia and epilepsy. The modified hypocaloric ketogenic diet preserves beta-cell mass and suppresses the deleterious effects of hyperinsulinaemia as a result of high-carbohydrate indulgence. The very-low-carbohydrate ketogenic diet possesses additive effects with coffee intake at several levels in the brain and peripheral organs. They may synergistically upregulate the sensitivity and levels of the present major anti-insulin resistance treatments of insulin, insulin sensitizers, glucagon-like peptide-based agents and adiponectin. They may also co-operate with exercise to enhance higher cognitive function, upregulate adiponectin- and GLP-I-induced suppression of the advanced glycation endproducts (AGE)-receptor for advanced glycation endproducts (RAGE) axis and attenuate the selective leptin resistance (SLR) in the metabolic syndrome. Present report shows that habitual coffee intake and very-low-carbohydrate ketogenic diet most significantly (P < 0.05) prevented rise of selected factors of BMI, FBS, triglycerides and HbAIc in non-diabetics than VLCKD or coffee alone. The combination also most significantly reversed the rise of these factors in subjects with the insulin resistance state. The combination thus attests to its eligibility in the prevention and reversal of type 2 diabetes mellitus in Nigerian adults.
Authors and Affiliations
Dr. S. E. Oriaifo
Keywords
Related Articles
- EP ID EP628329
- DOI -
- Views 165
- Downloads 0
EVALUATION OF TUBERCULOSIS DISEASE AWARENESS AND UNDERSTANDING AMONGST PHARMACY STUDENTS AT THE UNIVERSITY OF WOLVERHAMPTON
Introduction: Tuberculosis (TB) caused by the bacterium Mycobacterium tuberculosis is recognised as the leading cause of death due to infectious disease in the world. Pharmacies and pharmacy workers, together with GPs an...
THE OCCUPATIONAL RISK FACTORS FOR CANCER: A SURVEY AMONG THE ARTISANS IN THE CITY OF FEZ (MOROCCO)
Cancer is the second leading cause of mortality in Morocco. Data on occupational exposure related to cancer are still lacking. The objective of this study was to determine the frequency and the significance of the exposu...
KSHAPANA AND SHOASHANA IN URUSTAMBHA
Urustambha is a disease of Uru Pradesha in which there is occurrence of numbness, coldness, stiffness and immobility of thighs. Urustambha is a lifestyle disease and it is commonly seen in higher socioeconomic status. Su...
ANATOMICAL VARIATIONS AND THEIR CLINICAL SIGNIFICANCE IN POPULATION OF SOUTHWESTERN AND CENTRAL ETHIOPIA
The concept and contents of the anatomical variations is the history of the anatomy itself. Anatomical variations represent an embryological and comparative background in medicine and biology in order to understand the m...
BUCCAL BIOADHESIVE DRUG DELIVERY –A PROMISING OPTION FOR CONVENTIONAL THERAPY
Since, the last four decades, the concept of mucoadhesion has achieved a much valuable interest in the various fields of pharmaceutics. There are many advantages of mucoadhesive buccal drug delivery system that made this...