ORAL GLUCOSE TOLERANCE TEST (OGTT) WITH METHANOL EXTRACT OF SENNA OBTUSIFOLIA WHOLE PLANT
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 1
Abstract
Background. Senna obtusifolia is used in some traditional medicines as a blood glucose lowering agent in diabetic patients. The objective of the present study was to determine the antihyperglycemic effects of methanol extract of Senna obtusifolia whole plants in glucosechallenged mice. Methods. Antihyperglycemic activity was determined through oral glucose tolerance test (OGTT) in mice. Results. Administration of methanol extract of Senna obtusifolia whole plants (MESO) at doses of 50, 100, 200, and 400 mg per kg body weight each to glucose-loaded mice dose-dependently reduced blood glucose levels by 11.7, 20.1, 28.3, and 37.1%, respectively compared to control (untreated) mice. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 36.7%. Conclusion. Methanolic extract of whole plants of Senna obtusifolia can effectively lower elevated blood glucose levels, which at the highest dose tested was as effective as glibenclamide.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP620499
- DOI -
- Views 162
- Downloads 0
SOME ADVERSE EFFECTS OF FOSFOMYCIN IN RATS
The aim of this study was to determine the adverse effects of fosfomycin on liver, kidney functions which was evaluated by measuring liver and kidney enzymes and through histopathological examination of liver and kidney...
INITIATION OF TEAM- BASED LEARNING METHOD FOR PHARMACY PRACTICE EGYPTIAN EDUCATION
Introduction: Providing pharmaceutical care services with a high quality became a widespread standard in health care systems. To enable the next generation of pharmacists to meet these new challenges and allow them to dr...
KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS CERVICAL CANCER AND SCREENING FOR CERVICAL CANCER AMONG JUGAL HOSPITAL STAFFS, IN HARARI REGIONAL STATE, ETHIOPIA, 2017
Background: Cervical cancer was the fourth most frequently diagnosed cancer with an estimated 527,600 cases and the fourth leading cause of cancer death with 265,700 deaths among women worldwide in 2012. However, in deve...
COMPARISON OF ACUTE EFFECTS OF SUCRALOSE, ASPARTAME AND ACESULFAME POTASSIUM ON PULSE, BLOOD PRESSURE, AND BLOOD GLUCOSE LEVELS IN YOUNG HEALTHY ADULTS
Background: The use of non-nutritive sweeteners (NNSs) have become increasingly popular, so their health benefits and potential adverse effects should be evaluated. Methodology: This nonrandomized case-control comparativ...
KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS BLOOD DONATION AMONG MEDICAL STUDENTS IN TAIF UNIVERSITY
Background: Blood transfusion saves lives; the most imperative factor, which need blood, is road traffic accident on emergency department, the world health assembly (WHA 63) urges all the member states to develop nationa...