Organ and prenatal toxicity of nonsteroidal anti-inflammatory drugs
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2015, Vol 28, Issue 3
Abstract
Non-selective cyclooxygenase (COX) inhibitors, commonly referred to as nonsteroidal anti-inflammatory drugs (NSAIDs), are among the most taken pharmaceuticals. In adults, they can have a series of side effects, including especially gastroenterotoxicity, hepatotoxicity, nephrotoxicity, chondrotoxicity, and neurotoxicity, and they can induce allergic reactions. Any exacerbation of symptoms depends on the chemical structure of the drug, its dosage and duration of exposure, individual sensitivity, comorbidities and the degree of inhibition of basic COX isoenzymes – the constitutive (COX-2) and induced (COX-1) expressions. However, data on prenatal toxicity are inconsistent. Classic non-selective COX inhibitors do not result in an increase in the risk of developing significant congenital defects; however, if used in the late-pregnancy period, they can have an adverse effect on the foetus, by inducing the premature closure of the ductus arteriosus and by producing a tocolytic effect. Individual reports also indicate the increased risk of developing heart and anterior abdominal wall defects, as well as hypospadias.
Authors and Affiliations
Katarzyna Dyndor, Wojciech Dworzanski, Małgorzata Pliszczynska-Steuden, Monika Cendrowska-Pinkosz, Tomasz Chroscicki, Przemyslaw Dyndor, Anna Dworzanska, Ewa Piasek, Piotr Piech, Marcin Ruchala, Teresa Hermanowicz-Dryka
Keywords
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- EP ID EP128098
- DOI 10.1515/cipms-2015-0072
- Views 88
- Downloads 0
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