Original Research Article Study of Lipid Profile in People Living With Human Immunodeficiency Virus In Relation To Antiretroviral Therapy.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Background – Lipid Abnormalities Are Common In Hiv Infected Patients Due To Hiv Infection Itself And Antiretroviral Therapy, So We Tries To Study Pattern Of Lipid Profile In People Living With Hiv Infection And Changes In Different Fraction Of Lipid Profile In These Patients After Six Months Of Initiation Of First Line Art Regimen As Per Naco In A Tertiary Care Centre. Methods- This Observational Prospective Study Was Conducted For A Period Of Eighteen Months, On 75 Newly Registered Hiv-1 Infected Art Naive Patients Who Were Normotensive, Non-Diabetic, Non-Smoker, NonAlcoholic. Out Of Which 48 Patients Were Males And 27 Patients Were Females Of Age Group ≥ 15 Years With Appropriate Inclusion And Exclusion Criteria, Attending Art Centre In A Tertiary Care Hospital. Patients Were Started On First Line Art Regimen I.E. Tle Regimen As Per Current Naco Guidelines. 12 Hours Fasting Lipid Profile Were Analysed Enzymatically Before Initiation Of Art And Then Reviewed After 6 Months Of Art. Results – Study Concluded That There Was Significant Change In Different Fraction Of Lipid Profile In Hiv-1 Infected Patients After 6 Months Of Art. There Was Significant Rise In Tc From (139.0933 ± 25.57462 To 173.1200 ± 49.9846), Tg From (121.8600 ± 20.83492 To 144.3467 ± 35.2096), Ldl-C From (70.880 ± 28.0759 To 100.5840 ± 50.0037) With P-Value < 0.001 After 6 Months Of Art In Hiv-1 Infected Patients. Art Had No Significant Effect On Hdl-C At The End Of 6 Months. There Was Change In Hdl-C From (43.8360 ± 13.6018 To 43.2480 ± 13.0469) With P-Value 0.7874 I.E. > 0.05. Conclusion – Based On This Study We Conclude That Art Therapy Including Nnrti Based Regimen Caused Significant Lipid Abnormality I.E. Raised Tc, Tg, Ldlc In Art Receiving Patients After 6 Months. Thus Laying Emphasis On Need To Assess Lipid Profile At Beginning, Before Initiation Of Art And Monitor Any Rising Trend In Lipid Profile After 6 Months. These Lipid Abnormalities Predisposes These Patients To Development Of Cardiovascular Complications And Therefore Should Be Monitored.
Authors and Affiliations
Dr. Neeti Agrawal, Dr. Archana Gupta, Dr. Sushma Trikha
Keywords
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- EP ID EP373990
- DOI 10.9790/0853-1705025863.
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