Osmotic-Controlled Release Oral Delivery System: An Advanced Oral Delivery Form
Journal Title: The Pharma Innovation - Year 2012, Vol 1, Issue 7
Abstract
The osmotic-controlled release oral delivery system, OROS, is an advanced drug delivery technology that uses osmotic pressure as the driving force to deliver pharmacotherapy, usually once-daily, in several therapeutic areas. Oral route is one of the most extensively used routes of drug administration because of its obvious advantages of ease of administration, improved patient compliance and convenience. The main clinical benefits of OROS are their ability to improve treatment tolerability and patient compliance. These advantages are mainly driven by the capacity to deliver drugs in a sustained manner, independent of the drug chemical properties, of the patient’s physiological factors or concomitant food intake. However, access to these technologies has been restricted by the crowded patent landscape and manufacturing challenges. In this review, we intend to give an overview of the OROS development in the last 30 years, detailing the technologies, specific products and their clinical use. General guidance on technology selection is described in light of the recent advances in the field. The clinical performance of these technologies is also discussed, with a focus on food effects and the in vivo–in vitro correlation. Special attention is paid to safety given the controversial case study of Osmosin. Overall, oral osmotically driven systems appear to be a promising technology for product life-cycle strategies.
Authors and Affiliations
Nitika Ahuja , Vikash Kumar , Permender Rathee
Keywords
Related Articles
- EP ID EP98075
- DOI -
- Views 177
- Downloads 0
Phytochemical Investigation and Biological Activity of Leaves Extract of Plant Boswellia Serrata
Before onset of synthetic era, man was completely dependent on medicinal plants for prevention and treatment of diseases. Medicinal plants, herbs, spices and their remedies are known to ayurveda in India since long times...
A Comprehensive Review of Pulsatile Drug Delivery System
Novel Oral Drug Delivery technologies have emerged and expanded into different drug delivery system with different drug release mechanisms.Sophisticated instrumentation,modern mathematical models and computation power h...
Polysaccharides and Natural Gums for Colon Drug Delivery
The site‐specific delivery of the drugs to the target sites has the potential to reduce the side effects and improved the pharmacological response. The colon drug targeting is also exploited for systemic delivery of acti...
Diabetes Epidemic in India-- A Comprehensive Review of Clinical Features, Management and Remedies
India, the world’s second most populous country, now has more people with type 2 diabetes (more than 50 million) than any other nation. With India having the highest number of diabetic patients in the world, the sugar di...
Formulation and Evaluation of Buccal Patches of Simvastatin by Using Different Polymers
The objective of this study was to develop mucoadhesive buccal tablets of Simvastatin using mucoadhesive polymers. Simvastatin has short biological half-life (3hr), high first-pass metabolism and poor oral bioavailabilit...