Osteoarticular Tuberculosis: Clinical complexity, Laboratory challenges, Immunological intrigue
Journal Title: International Journal of Medical and Health Sciences - Year 2018, Vol 7, Issue 2
Abstract
Tuberculosis is a chronic disease caused by Mycobacterium tuberculosis and it continues to be a major health problem in developing countries. This problem is further compounded by the emergence of HIV co-infection and multidrug resistant tuberculosis. The majority of diagnosis is made on clinical, radiological grounds along with sputum microscopy. Cytokines reflect the inflammatory microenvironment; hence their study could be helpful in quantifying the progress of the disease and the beneficial effect of the treatment. These could serve as biomarkers signifying the end point of complete clinical and bacteriological cure. In this study we have studied a repertoire of different cytokines in osteoarticular tuberculosis, a paucibacillary disease. Changes in these immune parameters correlated with a significant clinical improvement, thereby providing a better understanding of the immunopathogenesis of the disease.
Authors and Affiliations
Urvashi Tiwari, V. G. Ramachandran, Shukla Das, Mohit Kumar Arora, Anuj Jain
Keywords
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