Ouabain and Endogenous Ouabain -Dr. Jekyll and Mr. Hyde of Cardiac Glycosides?
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 8, Issue 5
Abstract
In current research reports several disease states are claimed to be associated with elevated levels of endogenous ouabain. These include hypertension, cardiac enlargement, cardiac and renal failure, and a variety of terminal disorders. It has been suggested that endogenous ouabain should be considered as a major contributor to increased blood pressure and overall cardiovascular risk. These hypotheses stand in stark contrast to decades of clinical experiences with ouabain in humans, which indicate that plant-derived ouabain is effective in treating heart failure. In patients with hypertension ouabain lowers blood pressure. These conclusive clinical experiences refute the hypothesis that ouabain in humans is a major contributor to increased blood pressure and overall cardiovascular risk. The pronounced dependence of the ouabain effects on the dose, the state of the autonomic nervous system and species-specific characteristics in pharmacokinetics may explain many of the conflicting research results that have been published on experiments with ouabain. Rodents have different sensitivities to cardiac glycosides than humans. Pharmacokinetics of cardiac glycosides in rodents are also different from humans. Therefore, caution is advised when extrapolating experimental results in rodents to humans. The mutually exclusive effects of ouabain and the endogenous inhibitor of the Na/K-ATPase observed in mammalian tissues do not support the hypothesis that this inhibitor is identical with ouabain, but favour the interpretation that De Wardener’s “third factor” is something different, which also reacts to ouabain antibodies.
Authors and Affiliations
Hauke Fürstenwerth
Keywords
Related Articles
- EP ID EP348093
- DOI 10.9734/BJMMR/2015/17042
- Views 85
- Downloads 0
Carboxylated Osteocalcin and Adiponectin Correlate with Glycated Hemoglobin and 25(OH) Vitamin D Levels in Saudi Females with Type 2 Diabetes Mellitus Following Ingestion of Vitamin D Supplements
Background: Type 2 diabetes (T2D) is one of the fastest growing public health problems worldwide. Evidence linking vitamin D (VTD) status and T2D was reported. However, its role, and whether it acts directly or through s...
Dental Problems Associated with Hepatitis C Infection: A Report from Iran
Background: Infection with hepatitis C virus is a problem with global importance. Patients with HCV infection experience a wide spectrum of extrahepatic manifestations, a number of which occur in the oral cavity. Despite...
Application of Fractional Microneedling Radiofrequency and Autologous Platelet-Rich Plasma in Managing Facial Acne Scars
Background: Many treatment modalities were tried to treat acne scar & still big challenge for dermatologists. Radiofrequency is a non-ionizing electromagnetic radiation used in medicine for nearly 75 years and the applic...
Estradiol and/or Ibandronate Therapy Ameliorates A Case Series Describing the Outcomes of Treatment in Co-infected Patients with HIV and Hepatitis C on the United States-Mexico Border
According to the National Health and Nutrition Examination Survey 2007-2010 (NHANES) and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the prevalence of Hepatitis C in people of Hispanic descent is 1.5...
Gemcitabine and Carboplatin in Inoperable, Loco-Regionally Advanced and Metastatic Gallbladder Cancer- A Study from Northern Indian Cancer Institute
Aims: The primary objective of this study was to determine the response rates of the gemcitabine and carboplatin combination chemotherapy in treatment naïve patients with inoperable gall bladder cancer. The secondary obj...