Gemcitabine and Carboplatin in Inoperable, Loco-Regionally Advanced and Metastatic Gallbladder Cancer- A Study from Northern Indian Cancer Institute
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2017, Vol 19, Issue 12
Abstract
Aims: The primary objective of this study was to determine the response rates of the gemcitabine and carboplatin combination chemotherapy in treatment naïve patients with inoperable gall bladder cancer. The secondary objectives were to evaluate the toxicity, progression free survival (PFS), and overall survival (OS). Methodology: Treatment naïve patients with histologically proven inoperable gall bladder cancer treated with gemcitabine and carboplatin chemotherapy between February 2011 and December 2014 were included in this study. The dose of gemcitabine was 1 gm/m2 on day 1 and 8, and carboplatin [target AUC (area under the concentration versus time curve in mg/ml) of 5] on day 1, in a 21 day cycle. CT scan was used for response assessment. Results: There were 32 men and 92 women with a median age of 59 years (range 26-75 years). Of the 124 patients, 9 (7.3%) patients achieved a complete response and 54 (43.5%) patients achieved a partial response for an overall response rate of 50.8%. The median PFS was 4.6 months [95% confidence interval (CI) 4–5.5 months], with 1-year survival rate of 20.2%. Common toxicity criteria (CTC) grade 3 anaemia was seen in 6 (4.8%) patients. Grade 3 and 4 neutropenia was observed in 11 (8.9%) and 4 (3.2%) patients respectively, whereas 9 (7.3%) patients experienced Grade 3 thrombocytopenia. Conclusion: The combination of gemcitabine and carboplatin is active in advanced gall bladder carcinoma with mild toxicity.
Authors and Affiliations
Vineet Talwar, Shubhra Raina, Varun Goel, Dinesh C. Doval
Keywords
Related Articles
- EP ID EP311398
- DOI 10.9734/BJMMR/2017/30843
- Views 81
- Downloads 0
Gemcitabine and Carboplatin in Inoperable, Loco-Regionally Advanced and Metastatic Gallbladder Cancer- A Study from Northern Indian Cancer Institute
Aims: The primary objective of this study was to determine the response rates of the gemcitabine and carboplatin combination chemotherapy in treatment naïve patients with inoperable gall bladder cancer. The secondary obj...
Diagnosing Cerebral Venous Sinus Thrombosis on Unenhanced Computed Tomography -Measuring the Hounsfield Unit. Does it Add to the Confirmation of Diagnosis?
Background: Over past decade, epidemiology of cerebral venous sinus thrombosis (CVST) has significantly changed. CVST is being diagnosed clinically and by non- invasive imaging techniques early in its course and has bett...
Erupting Odontome- A Compilation of Two Rare Case Reports
Odontomas are the most common type of benign odontogenic tumours; they are asymptomatic and are often discovered during routine radiographs of the jaws. Odontomes can be used as stem cell reservoirs and generally eruptio...
A Negative Association between Social Support and Depression in the Elderly Population of Amirkola City
Introduction: Depression is one of the most common psychiatric disorders in old age. The aim of the study was to investigate the relationship between social support and depression in elderly population of Amirkola city,...
Sero-negative Antibody Status in HIV-Infected Children Initiated on Early Anti-Retroviral Therapy in Jos, Nigeria
Aim: To determine the association between the age at initiation of anti-retroviral therapy (ART) and the 18 month antibody status of human immunodeficiency virus (HIV)-infected children in Jos, Nigeria. Study Design: Thi...