Outcome of Dexamethasone cyclophosphamide pulse therapy in immunobullous disorders: a prospective study from a tertiary Centre in north Kerala, India
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 5
Abstract
Background: Dexamethasone – Cyclophosphamide Pulse (DCP) therapy has created miracles in the treatment of pemphigus group of diseases. It has given the patient a chance to cure rather than control of the disease. Aims: The objective of the study was to assess the efficacy and side effects of DCP therapy. Methods: Patients who had been treated with DCP therapy from 2004 to 2012 were prospectively assessed and analyzed. Results: A total of 64 patients were treated with DCP ranging from 20-71 years. Male to female ratio being 1:1.37. Most of the patients were pemphigus vulgaris (58), 3 had pemphigus foliaceous, pemphigus erythematosus in two patients and one patient had bullous pemphigoid. Twenty five patients have completed more than two years after phase IV and have been considered as cured. Three patients are in phase I, 7 in phase II, 1 in phase III and 6 in phase IV. There were eight relapses and five patients died. Side effects were mostly minor and treatable without discontinuing DCP. Conclusion: DCP therapy is a real boon in the treatment of pemphigus group of patients. It was found to be very effective with minimal serious side effects.
Authors and Affiliations
Dr. RAHIMA S
Keywords
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