Outcomes of Acute Kidney Injury Patients with and Without Cancer: A Single Center Study
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 7, Issue 4
Abstract
Background: Acute kidney injury (AKI) is a frequent complication in hospitalized patients. Incidence of AKI in hospitalized patients with cancer is increasing, but there have been few studies on AKI in patients with cancer. The purposes of this study were: 1. To evaluate and compare the characteristics and outcomes of cancer and non-cancer AKI patients; 2. To determine the impact of cancer diagnosis on hospital mortality of AKI patients; and 3. To compare outcome predictors between the two groups of AKI patients. Methods: We conducted a retrospective cohort study in a South Korean tertiary care hospital. A total of 2211 consecutive patients (without cancer 61.5%; with cancer 38.5%) were included over a 140-month period. Predictors of all-cause death were examined using the Kaplan-Meier method and the Cox proportional hazards model. Results: The main contributing factors of AKI were sepsis (31.1%) and ischemia (52.7%). AKI was multifactorial in 78% of patients with cancer and in 71% of patients without cancer. Hospital mortality rates were higher in patients with cancer (42.8%) than in patients without cancer (22.5%) (P = 0.014). In multivariate analyses, diabetes mellitus (DM) and cancer diagnosis were associated with hospital mortality. Cancer diagnosis was independently associated with mortality [odds ratio = 3.010 (95% confidence interval, 2.340-3.873), P = 0.001]. Kaplan-Meier analysis revealed that subjects with DM and cancer (n = 146) had lower survival rates than subjects with DM and without cancer (n = 687) (log rank test, P = 0.001). Conclusion: The presence of DM and cancer were independently associated with mortality in AKI patients both with and without cancer. Studies are warranted to determine whether proactive measures may limit AKI and improve outcomes.
Authors and Affiliations
Juwon Lee, Ye Na Kim, Ho Sik Shin
Keywords
Related Articles
- EP ID EP347744
- DOI 10.9734/BJMMR/2015/15899
- Views 62
- Downloads 0
Rare Case of Multifocal Cutaneous Tuberculosis Verrucosa Cutis: Posing Clinical and Histopathological Diagnostic Dilemma
Introduction: Tuberculosis is an ancient universal health problem, with cutaneous tuberculosis being a rare extra pulmonary form that accounts for only 0.15-2%. Here we report a case of elderly female diagnosed with mult...
Molecular Identification of Mycobacterium bovis from Post-mortem Inspected Cattle at the Abattoir and Slaughter Houses in Bauchi State, Nigeria
Aims: Bovine tuberculosis (bTB) is a chronic infectious and contagious zoonotic disease of domestic, wild animals and humans. The disease occurs in a wide range of mammalian species and therefore, poses a public health t...
Ouabain and Endogenous Ouabain -Dr. Jekyll and Mr. Hyde of Cardiac Glycosides?
In current research reports several disease states are claimed to be associated with elevated levels of endogenous ouabain. These include hypertension, cardiac enlargement, cardiac and renal failure, and a variety of ter...
Effective Physical Therapy Treatment of Post-Cesarean Section Low Back Pain – Case Report
Introduction: Treatment of low back pain after cesarean section has been studied with exercise programs, but there has been little with a full physical therapy treatment plan involving manual therapy and therapeutic exer...
Falls in Elderly with Plantar Changes
Aims: The purpose of this study was to evaluate the prevalence of falls among older people with plantar changes in order to preserve their autonomy and independence. Study Design: A cross-sectional, descriptive, analytic...