Oxidative Stress and Antioxidant Status Before and after Grafting in Diabetic Patients with Foot Ulcer
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 10
Abstract
Introduction: Diabetic foot ulcer (DFU) is the third most common complication and it is estimated that 85% of lower limb amputation in diabetes patients are preceded by foot ulcers. Oxidative stress plays a significant role in regulating normal wound healing by facilitating hemostasis, inflammation, wound closure, and development and maturation of the extracellular matrix. So we evaluated oxidative stress and antioxidant status in diabetic patients with foot ulcers before and after grafting. Material and methods: It was a prospective longitudinal study in Rajah Muthiah medical college, chidambram, and comprised of 40 subjects. Written informed consent was obtained from all patients before the study. Blood samples were collected three times during the study i.e on the day of admission, on the preoperative day and on the 5th post operative day. All the samples were stored at -80o till the analysis. Results: Biochemical parameters were analyzed on day of admission, day before and five days after grafting. There was a significant reduction of MDA but there was no significant change in antioxidant status. Conclusion: In diabetic patients with chronic non healing wound, lymphocyte apoptosis is initiated by the augmentation of reactive oxygen species which leads to the increased expression of proapoptotic proteins and decreased expression of antiapoptotic proteins. But there was no change in antioxidant status. Reduced oxidative stress could be due to reduced inflammation. To conclude, there was reduction of oxidative stress after grafting which would help in wound healing in diabetic foot ulcer.
Authors and Affiliations
Selvam Prasannabalaji, Govindarajan Ashok Swaminathan, Subramaniam Sethupathy
Keywords
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