Oxidative Stress and Serum Ferritin Status in Rheumatoid Arthritis Patients.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2015, Vol 4, Issue 4
Abstract
Aim : The study was aimed to study the serum ferritin level as a response to oxidative stress in Rheumatoid arthritis patients and to measure the degree of oxidative stress in them by estimating the level of vitamin C. Methods: The study included 50 patients who were clinically diagnosed as patients with RA and 50 age and sex matched healthy volunteers. Blood samples were collected from them and serum ferritin and serum vitamin C were estimated. Results: The level of Vitamin C was found to be significantly decreased in the patients than in the healthy controls. Whereas, serum ferritin level showed significant rise in the patients as compared to the healthy controls. Conclusions: The significant rise in serum ferritin is highly associated with higher oxidative stress in rheumatoid arthritis patients as compared to the normal healthy controls. Serum ferritin acts as an acute phase reactant and its rise is due to inflammatory response to the rising oxidative stress in rheumatoid arthritis.
Authors and Affiliations
Sapkota S| Assistant Professor, Agriculture and Forestry University, Nepal, Shakya L| Department of Biochemistry, Shree Medical and technical College, Bharatpur, Nepal
Keywords
Related Articles
- EP ID EP3591
- DOI -
- Views 392
- Downloads 27
EFFECTS ON HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL CHANGES AFTER PRETREATMENT WITH THE KCNQ OPENER RETIGABINE AND DIACYGLYCEROL LIPASE INHIBITOR ON PROPOFOL IN THE MICE
The mechanisms of action of general anesthetics are still being unraveled. Retigabine is a KCNQ/Kv7 channel opener and has potential therapeutic importance for epilepsy. On the other hand, Propofol an inducing general an...
MEDICINAL PLANTS WITH POTENTIAL HYPOGLYCEMIC PROPERTY-A REVIEW
Diabetes mellitus is a clinical syndrome characterized by a deficiency in insulin production or resistance to insulin action. Consequently, it leads to inappropriate hyperglycemia. Prolonged hyperglycemia can cause sever...
RP-HPLC assay method development and validation of ketorolac and olopatidine in opthalmic liquid dosage forms
A simple reverse phase high performance liquid chromatographic assay method was developed and validated for the simultaneous estimation of Ketorolac and olopatadine in ophthalmic liquid dosage forms. The chromatographic...
HPTLC FINGERPRINT PROFILE OF STEROIDAL CONSTITUENTS OF ACHYRANTHES ASPERA LINN.
The study was carried out with an aim to determine the steroidal profile of the medicinally important plant Achyranthes aspera Linn. from methanolic extract of root, stem and leaf. Preliminary phytochemical screening was...
HAEMOGLOBIN F LEVEL AND HAEMATOLOGICAL FEATURE AMONG SUDANESE CHILDREN WITH SICKLE CELL ANAEMIA UNDERGOING HYDROXYUREA THERAPY
Sickle cell anemia (SCA) is one of the major types of anemia found in Sudan.The aim of this study is to evaluate the effect of Hydroxyurea (HU) treatment on Hb F level, reticulocyte count and the haematological feature a...