Oxidative Stress, Antioxidant Status and Inflammation in Chronic Bronchitis and Pulmonary Emphysema
Journal Title: Archives of Pulmonology and Respiratory Care - Year 2017, Vol 3, Issue 1
Abstract
Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized by a complex range of pathological changes including both pulmonary and systemic effects. Several mechanisms contribute to the variable intermediate and clinically relevant disease phenotypes, such as chronic bronchitis and emphysema, and systemic disease. The molecular mechanisms associated to the pathogenesis of COPD are not yet clearly understood. Objective: The aim of this study was to evaluate oxidant/antioxidant balance and the systemic inflammation in chronic bronchitis and pulmonary emphysema COPD patients. Methods: We analyzed COPD patients divided in 2 groups: chronic bronchitis and emphysema. Healthy volunteers without lung disease were used as control group. Results: We observed a significant (P<0,05) increase in the levels of plasma malondialdehyde (MDA), a marker of oxidative stress, an increase in the circulating C-reactive protein (CRP), used as a biomarker of systemic inflammation, and a decrease in antioxidant defense in COPD patients with emphysema when compared with COPD patients with chronic bronchitis. Conclusion: Althought our results should be regarded as preliminary they indicate a disturbance in oxidant/antioxidant status and systemic inflammatory response associated to COPD patients. The differences observed were more evident in emphysematous phenotype.
Authors and Affiliations
Cristóvão Cristina, Nogueira Fernando, Bicho Manuel
Keywords
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- EP ID EP340618
- DOI 10.17352/aprc.000015
- Views 78
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