Oxidative Stress, Endothelial Dysfunction, Inflammation and Impaired Coagulopathy in Prediabetic Individuals
Journal Title: International Journal of Research and Review - Year 2018, Vol 5, Issue 4
Abstract
Background and objectives: Prediabetic is the precursor state of the disease Diabetic Mellitus (DM).It is a metabolic diathesis with high blood sugar and dyslipidaemia. This increases the risk for the development of DM and cardiovascular diseases. The prediabetic state is classified into: - (1) the impaired fasting glycemia (IFG) and (2) impaired glucose tolerance (IGT). WHO has defined impaired fasting glucose level as 110 to 125mg% and impaired glucose tolerance as that 2hour plasma glucose to be within the range of 140 to 200 mg% after a oral glucose load of 75grams. Hence, this study was designed to(1) evaluate the role oxidative stress, endothelial dysfunction , inflammation (2) find diagnostic markers for early detection of changes in prediabetes to prevent DM. Material and method: This case control study included 112prediabetic individuals and an equal number of matched healthy volunteers. The FBG, lipid profile, HbA1c and CRP were estimated. We used ferrous oxidation in xylenol orange version 2 (FOX2) assay to estimate the level of oxidative load and FRAP assay for total antioxidant capacity; ratio of FOX2 & FRAP assay provided the oxidative stress level. We estimated endothelial dysfunction by serum nitric oxide (NO) level, inflammation by CRP and coagulopathy by plasma Fibrinogen level. Results: A positive correlation was seen between oxidative stress, glycated haemoglobin, inflammation and dyslipidemia and negative correlation with serum nitric acid. Conclusion: Biomarkers of oxidative stress, inflammation, dyslipidemia, serum nitric oxide should be monitered along with, glycated haemoglobin in prediabetic patients so that DM can be prevented.
Authors and Affiliations
Dr. Upendra Kumar Das
Keywords
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